头孢呋辛、头孢唑啉和氨苄西林对β-内酰胺酶稳定性的比较研究  

Comparison study on the stability to β-lactamases amony Cefuroxime、Cefazolin and Ampicillin

作　　者：张莉[1] 匡湘红[1] 田汉文 杨新云[1] 范爱兰[1] 

机构地区：[1]华西医科大学药理教研室,成都610041

出　　处：《四川生理科学杂志》1999年第2期29-31,共3页Sichuan Journal of Physiological Sciences

摘　　要：本文比较研究了三种有代表性的β-内酰胺类抗生素氨苄西林、头孢唑啉和头孢呋辛对β-内酰胺酶的稳定性。结果表明三者中以头孢呋辛的酶水解率较低即对酶较为稳定;氨苄西林对酶的稳定性其次;而头孢唑啉的酶水解率较高即易被酶水解破坏而失去抗菌活性,但头孢唑啉添加舒巴坦(按1:1配比)后对酶稳定性明显提高。The aim of this study was to compare the stability to β-lactamase amony the three β-lactam antibioties which are used commonly in clinic i. e. Cefuroxime, Cefazolin and Ampicillin. 5 standard β-lactamases and 2 isolated clinical bacterial β-lactamases were used to determine the absolute rates of hydrolysis to the antibiotics by spectropho-tometric assay. The result showed that the hydrolysis rates of cefuroxime were lower than that of cefazolin and Ampicillin. While the hydrolysis rates of cefazolin/sulbactam (1:1) were lower than that of cefazolin alone. It was concluded that cefuroxime was the most stable one to β-lactamares amony the three antibiotics while cefazolin was easy to be damaged by β-lactamases. Sulbactam can increase the stability of cefazolin to β-laclamases, which is worth to study in detail.

关 键 词：头孢呋辛 头孢唑啉 氨苄西林 Β-内酰胺酶 稳定性 

分 类 号：R96[医药卫生—药理学]