Synthesis of N^6-Cyclopropy1-2,6-diamino-9 β-D-arabinofuranosylpurine  

作　　者：Jun Biao CHANG Rut Yun GUO Juan HE Rong Fend CHEN (Henan Institute of Chemistry. Zhengzhou 450003) 

出　　处：《Chinese Chemical Letters》1999年第5期357-360,共4页中国化学快报（英文版）

摘　　要：Synthesis of N6-cyclopropy1-2.6-diamino-9 β-D-arabinofuranosyl-purine has beenaccomplished by treatment silylated 2-amino-6-chloro-purine 4 with 2.3.5-tri-O-benzyl- β-Darabinofuranosyl chloride 3 in the presence of molecular sieves. followed by reaction withcyclopropylamine and debenzyl reaction to give the β-anomeric nucleoside. The structures ofall products were confirmed by UV. 'H-NMR and elemental analysis.Synthesis of N6-cyclopropy1-2.6-diamino-9 β-D-arabinofuranosyl-purine has beenaccomplished by treatment silylated 2-amino-6-chloro-purine 4 with 2.3.5-tri-O-benzyl- β-Darabinofuranosyl chloride 3 in the presence of molecular sieves. followed by reaction withcyclopropylamine and debenzyl reaction to give the β-anomeric nucleoside. The structures ofall products were confirmed by UV. 'H-NMR and elemental analysis.

关 键 词：CYCLOPROPYLAMINE arabinofuranose purnie 

分 类 号：O621[理学—有机化学]