Synthesis and Stereostructure of New β-Lactam Derivatives of1,5-Benzothiazepines  

Synthesis and Stereostructure of New α-Lactam Derivatives of 1,5-Benzothiazepines

作　　者：Yuan LI Na SUN Sheng JIN(Department of Chemistry Hebei University Shijiazhuang 050016 Institute of Chemistry and Molecular Engineering Peking University Beijing 100871) 

出　　处：《Chinese Chemical Letters》1999年第6期447-448,共2页中国化学快报（英文版）

摘　　要：Reaction of 1,5-benzothiazepine with N-protected glycine gives new a-amino-β-lactamderivatives of 1.5-benzothiazepine. The configuration and conformation of the products wereconfirmed by x-ray diffraction. The result further reveals that the reaction of 1.5-benzothiazepineswith derivatives of carboxylic acid stereospecific.Reaction of 1,5-benzothiazepine with N-protected glycine gives new a-amino-β-lactamderivatives of 1.5-benzothiazepine. The configuration and conformation of the products wereconfirmed by x-ray diffraction. The result further reveals that the reaction of 1.5-benzothiazepineswith derivatives of carboxylic acid stereospecific.

关 键 词：1.5-Benzothiazepine Β-LACTAM stereospecific reaction 

分 类 号：O621[理学—有机化学]