Secondary Structurc in Solution of an Analog of Salmon Calcitonin:[Val^1, Ala^7]sCT  

作　　者：Bin YANG  Hou Li JIANG Zhen Kai DING Qi Kai ZHANG(Beijing Institute of Pharmacology and Toxicology Beijing 100850National Center of Biomedical Analysis. Beijing 100850) 

出　　处：《Chinese Chemical Letters》1999年第7期555-558,共4页中国化学快报（英文版）

摘　　要：Secondary structure of [Val. Ala]sCT- an analog of salmon calcitonin (sCT) not containing an N-terminal disultide bridge. was investigated by circular dichroism (CD) and Fourier-transform intrared spectroscopy (FTIR) methods. Both CD and FTIR results show that the main contbrmational structure of [Val Ala']sCT in aqueous solution is random coil structure. while in trifluorethanol (TFE) it displays a strong α-helical structure. The relationship between the biological activity and the conformational structure of [Val, Ala] sCT is als0 discussed.Secondary structure of [Val. Ala]sCT- an analog of salmon calcitonin (sCT) not containing an N-terminal disultide bridge. was investigated by circular dichroism (CD) and Fourier-transform intrared spectroscopy (FTIR) methods. Both CD and FTIR results show that the main contbrmational structure of [Val Ala']sCT in aqueous solution is random coil structure. while in trifluorethanol (TFE) it displays a strong α-helical structure. The relationship between the biological activity and the conformational structure of [Val, Ala] sCT is als0 discussed.

关 键 词：Salmon calcitonin analog CD FTIR peptide secondary structure 

分 类 号：O629[理学—有机化学]