环孢素引起肝损害的治疗研究  

Study on nephroxicity induced by cyclosprine A

作　　者：孙淑清[1] 王立国[1] 高占军[1] 刘建平[1] 闫宏亮[1] 

机构地区：[1]吉林军医学院附属医院,吉林市132013

出　　处：《空军医高专学报》1999年第4期204-206,共3页

摘　　要：目的:观察山莨菪碱、护肝片加片仔癀治疗肾移植术后环孢素性肝损害的疗效,寻找有效的治疗方法.方法:将肾移植术后28例环孢素性肝损害患者分为两组;A组:山莨菪碱40mg加入5%葡萄糖注射液中,每天1次静点或1Omg每日4次口服;B组:护肝片3片、片仔癀2片,每天3次口服.结果A组16例中有15例治愈(占93.8%),好转1例(占6.3%);B组12例中有3例好转(占25.O%),无效9例(占75.0%).结论:治疗肾移植术后环孢素性肝损害,山莨碱明显优于护肝片和片仔癀.ve: To evaluate the curative effect of anisodamine and Liver-Aid (sugar-coated tablet) plus Pian Tze Huang on nephroxicity induced by cyclosprine A(CsA). Method:Twenty-eight renal transplant recipients with nephroxicity induced by CsA were randomly divided into two groups. Group A ( n = 16) received anisodamine intravenously (40 mg in 5 % glucose injection, once a day) or orally (10 mg,4 times a day); Group B ( n - 12) orally received Liver-Aid (3 tablets,3 times a day) and Pian Tze Huang (2 tablets, 3 times a day). Result: In group A,93.8 % (15/16) of the patients were cured and6.3 % (1/16) improved . In group B,25.0 % (3/12) of the patients were improved and 75.0 % (9/12)ineffica-cy. Conclusion: Anisodamine was much more effective than Liver-Aid plus Pian Tze Huang in treatment of nephroxicity induced by CsA.

关 键 词：肾移植 环孢素 肝毒性 

分 类 号：R595.3[医药卫生—内科学]