烧伤患者血浆IL-8、VCAM-1的变化与呼吸功能障碍的关系  

The plasma levels of IL-8 and VCAM-1 concentrations in different burn area patients with or without lung dysfunction

作　　者：陈玉林[1] 韦多[1] 郇京宁[1] 衣承东[1] 李元义[1] 鲁彩霞[1] 李智[1] 沈洪兴[1] 

机构地区：[1]第二军医大学长海医院烧伤科

出　　处：《第二军医大学学报》1998年第S1期13-14,共2页Academic Journal of Second Military Medical University

摘　　要：目的：探讨烧伤后血浆白细胞介素８（ＩＬ－８）、血管细胞粘附分子１（ＶＣＡＭ－１）变化与烧伤严重程度及呼吸功能障碍的关系。方法：对１８例ＴＢＳＡ为３５％～９７％的烧伤患者，分别于伤后１２ｈ，１，２，４，７ｄ取血，分离血浆，采用ＥＬＩＳＡ法测定１Ｌ－８和ＶＡＣＭ－１的水平。结果：ＴＢＳＡ＜５０％组伤后血浆ＩＬ－８水平持续升高，于伤后第４天达峰值。ＴＢＳＡ＞５０％组各时相点水平明显高于ＴＢＳＡ＜５０％组，两组相比差异显著（Ｐ＜０．０５）。出现肺功能障碍组ＩＬ－８水平明显高于无肺功能障碍组。ＴＢＳＡ＞５０％组和肺功能障碍组ＶＣＡＭ－１水平明显高于正常对照组、ＴＢＳＡ＜５０％组及无肺功能障碍组（Ｐ＜０．０５）。结论：热损伤后ＩＬ－８与ＶＣＡＭ－１能影响全身免疫反应，并与肺功能障碍的发生、发展有关。烧伤面积大小。Objective: To observe the alterations of plasma levels of IL-8 and VACM-1 in different burn area patients and their roles in burns accompanied by lung dysfunction. Methods: The plasma was separated from blood samples of 18 patients 12 h and 1,2,4, 7 d postburn (PB). The IL8 and VACM1 in plasma were detected by ELISA kit (Genzyme). Results: The plasma level of IL8 in TBSA<50% group increased continuously and reached at a peak in PB 4 d. The IL-8 level of TBSA≥50% group had an abrupt elevation and was significantly higher than those of TBSA<50% group in PB 4, 7 d(P<0.01). The plasma level of IL-8 in lung dysfunction group was also significantly higher than that in normal lung function group in PB 4,7 d(P<0.01). The changes of plasma VACM-1 were similar to those of IL-8 in each group. Conclusion: The alterations of plasma IL-8 and VACM levels are influenced by severity of burn and dysfunction of lung in thermal injuries.

关 键 词：白细胞介素8 血管细胞粘附分子1 烧伤 肺功能障碍 

分 类 号：R644.03[医药卫生—外科学]