严重烧伤后血浆IL-12浓度的变化  

Change of plasma level of IL-12 in patients with severe thermal injury

作　　者：李智[1,2] 陈玉林[1,2] 李树贞[1,2] 夏照帆[1,2] 韦多[1,2] 刘世康[1,2] 李元义[1,2] 衣承东[1,2] 沈洪兴[1,2] 

机构地区：[1]第二军医大学长海医院烧伤科 [2]第二军医大学护理系

出　　处：《第二军医大学学报》1998年第S1期29-31,共3页Academic Journal of Second Military Medical University

摘　　要：目的：研究严重烧伤后血浆ＩＬ－１２浓度的变化及其意义。方法：ＥＬＩＳＡ法检测１８例严重烧伤患者伤后２周内的血浆ＩＬ－１２浓度。结果：在４０％≤ＴＢＳＡ≤６０％组ＩＬ－１２血浆浓度最低值显著高于ＴＢＳＡ＞６０％组；首次切痂后血浆ＩＬ－１２血浆浓度要高于手术前。结论：烧伤程度越重。Objective: To study the change of plasma level of IL-12 in patients with severe thermal injury. Methods: Plasma levels of IL-12 in patients with severe thermal injury were measured for a couple of weeks using the enzyme-linked immunosorbent assay kit.　Results: The lowest plasma levels of IL-12 in patients with considerable minor burn injury (40%≤TBSA≤60%) were significantly higher than those in patients with severe burn injury (TBSA>60%). The patients showed significantly higher plasma levels of IL-12 after escharectomy compared with those determined preoperatively. Conclusion: The more the severity of burn injury, the more the resistance to IL-12 production.

关 键 词：烧伤 白细胞介素12 感染 

分 类 号：R644.03[医药卫生—外科学]