增生性瘢痕组织P物质及其受体分布的免疫组织化学研究  

Immunohistochemical Study on Substance P and Substance P Receptor Distribution in Hypertrophic Scar Tissue

作　　者：丛林 李世荣[1,2] 梁智勇 

机构地区：[1]解放军第二一O医院烧伤整形科 [2]第三军医大学附属西南医院整形外科

出　　处：《中华创伤杂志》1998年第S1期67-69,共3页Chinese Journal of Trauma

摘　　要：目的研究Ｐ物质（ＳＰ）及其受体（ＳＰＲ）在人皮肤增生性瘢痕组织中的分布。方法应用免疫组织化学链霉菌抗生物素蛋白－过氧化酶连接法检测增生性瘢痕、非增生性瘢痕及正常皮肤组织中ＳＰ和ＳＰＲ的分布；并用图像分析仪对染色结果进行半定量分析。结果皮肤及瘢痕组织中均能检测到ＳＰ和ＳＰＲ，增生性瘢痕组织中ＳＰ和ＳＰＲ分布密度显著高于非增生性瘢痕及正常皮肤，ＳＰ和ＳＰＲ在同一部位分布并不完全一致。Aim To investigate the distribution of substance P (SP) and substance P receptor (SPR) in human hypertrophic scar tissue. Methods We detected the distribution of SP and SPR in human hypertrophic scar, non hypertrophic scar and the normal skin immunohistochemically and the quantitative analysis by image analysis system was employed. Results The distribution density of SP and SPR in the hypertrophic scar was significantly higher than that in the non hypertrophic scar and in the normal skin. The distribution pattern of SP was not exactly the same as that of SPR in some regions . Conclusion SP and SPR may play an important role in the process of hypertrophic scar development.

关 键 词：瘢痕 P物质 受体 免疫组织化学 

分 类 号：R619.603[医药卫生—外科学]