全麻效应的受体机制  

Receptor mechanism of general anesthesia

作　　者：王殿仕[1] 庞志平[1] 徐天乐[1] 

机构地区：[1]第四军医大学解剖学教研室

出　　处：《中国药理学通报》1998年第S1期26-29,共4页Chinese Pharmacological Bulletin

摘　　要：随着配体门控型离子通道分子克隆研究技术的发展,对由特定亚单位组成的重组受体的药理学研究成为可能。近年来,许多实验室应用此技术对产生全麻效应的麻醉药的作用机制进行了研究。大多数吸入性和静脉麻醉药对GABA_A受体有不同程度的增强调制作用。甘氨酸,AMPA,红藻氨酸,NMDA以及5-HT_3受体等也都是许多麻醉药的作用靶。某些全麻药对受体作用的亚单位特异性提示,通过构建和研究嵌合受体可能最终会找出决定全麻效应的特定氨基酸序列。Molecular cloning of cDNAs coding for ligand-gated ion channel subunits makes it possible to study the pharmacology of recombinant receptors with defined subunit compositions. Many laboratories have used these techniques recently to study actions of agents that produce general anesthesia. Most of the volatile and intravenous anesthetics potentiate the function of GABAA receptor to different extent. Glycine, AMPA, kainate,NMDA, and 5-HT3 recepors are also the targets for many anesthetics. Subunit specific actions of some of the agents suggest that construction and testing of certain chimeric receptor subunits may be useful for defining the amino acid sequences responsible for anesthetic actions.

关 键 词：全身麻醉药 A型γ-氨基丁酸受体 甘氨酸受体 N-甲基-D-门冬氨酸受体 谷氨酸受体 

分 类 号：R614.2[医药卫生—麻醉学]