异丙酚在快速顺序插管时低血压的预防  

PROPHYLAXIS AGAINST THE SYSTEMIC HYPOTENSION INDUCED BY PROPOFOL DURING RAPID SEQUENCE INTUBATION

作　　者：马武华[1] 蔡君[1] 陈秉学[1] 沈宁[1] 蔡茂中 

机构地区：[1]中山医科大学

出　　处：《中山大学学报（医学科学版）》1998年第S1期90-91,95,共3页Journal of Sun Yat-Sen University:Medical Sciences

摘　　要：目的：对麻黄碱和血定安两种方法预防异丙酚诱导引起的低血压进行比较。方法：４５例行ＦＥＳＳ（功能性鼻内窥镜）手术患者，随机分成３组，每组各１５例。Ａ组：在诱导前不接受任何处理；Ｂ组：在诱导前给予麻黄碱０．１ｍｇ／ｋｇ静注，Ｃ组：在诱导前３０ｍｉｎ内先用血定安８ｍＬ／ｋｇ进行扩容，然后分别在入室后１０ｍｉｎ、诱导前、诱导后２、５ｍｉｎ、插管即刻、插管后５、１０、１５ｍｉｎ时分别记录ＳＰ（收缩压）、ＤＰ（舒张压）、ＭＡＰ（平均动脉压）和ＨＲ（心率）的变化并进行比较。结果：Ｂ组血压在诱导后２、５ｍｉｎ时的降低幅度明显小于Ａ组且差异有显著性意义，插管后血压均高于Ａ组，Ｃ组各时间和Ａ组比较Ｐ＞０．０５。结论：麻黄素０．１ｍｇ／ｋｇ可预防异丙酚诱导后和插管后５～１５ｍｉｎ内的低血压。Objective:To study the preventive effects of ephedrine or gelofusine on hypotension after propofol induction.Method:Forty five patients,ASA Ⅰ～Ⅱ,undergoing FESS,were randomly divided into three equal groups of fifteen each.Group A: no drugs were given before induction,group B: a dose of ephedrine 0.1mg/kg was given before induction and group C: gelofusine 8mL/kg was given 30 min before induction as volume expands.SP、DP、MAP and HP were monitored at 10 minute after entering the operation room, before induction and 5,10,and 15 min after intubation. Resutts: 5 min after induction BP in group B was slightly higher than group A.When group C was compared to group A,no significance was found.Coclusion:Ephedrine(0.1mg/kg) may satisfactorily prevent post induction and post intubation hypotension induced by propofol.

关 键 词：二异丙酚/副作用 插管法.气管内 低血压/预防和控制 麻黄碱/治疗应用 

分 类 号：R614.2[医药卫生—麻醉学]