舒心饮对豚鼠心脏再灌注冠脉流液前列腺素、心肌内皮素和脂质过氧化物的影响  

Effect of Shuxinyin(舒心饮)on Prostaglandins,Myocardial Endothelin and Lipid Peroxide in Ischemia-Referfusion Isolated Heart of Guinea-Pigs

作　　者：刘宇[1] 林钟香[1] 顾仁樾[1] 

机构地区：[1]上海中医药大学附属龙华医院,上海200032

出　　处：《中国中西医结合杂志》1998年第S1期6-9,352,共5页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的:观察舒心饮对豚鼠心脏缺血再灌注的改善作用。方法:将豚鼠随机分为3组(对照组、缺血组、舒心饮组),观察舒心饮对豚鼠心脏缺血再灌注后冠脉流液中血栓素B2、6-酮-前列腺素 F_(1α)心肌组织内皮素和脂质过氧化物的影响。结果:对缺血后损伤的心肌, 于再灌注的同时给予舒心饮(1.6g/L),明显抑制血栓素 A_2的释放,促进前列环素I_2的产生,减少心肌内皮素的含量,加速清除氧自由基降低心肌组织脂质过氧化物的含量。结论:舒心饮具有抗心肌缺血的作用。Objective:To observe the ameliorative effect of Shuxinyin (SXY) on ischemia-reperfusion isolated heart in guinea- pigs.Methods:Experimental animals were divided randomly into 3 groups:The control group,the ischemic group and the SXY group,and their thromboxane A_2(TXA_2),6-keto-prostaglandin F_(1a)(6KP) in perfusion fluid,myocardial endothelin (ET)and lipid peroxide(LPO)were observed after ischemia-reperfusion.Results:When SXY was given simultaneously with reperfusion after ischemia,it could decrease the release of TXA_2,increase the production of 6KP,decrease myocar- dial ET and scavenge oxygen free radicals and reduce myocardial LPO.Conclusion:SXY could protect the myocardium from ischemia-reperfusion injury.

关 键 词：舒心饮 血栓素 B₂ 6-酮-前列腺素 F_1α 内皮素 脂质过氧化物 

分 类 号：R285.5[医药卫生—中药学]