川芎嗪对犬肾动脉成形术前后血小板功能和TXA_2/PGI_2平衡变化的实验研究  

Experimental Study on Effects of Drugs on Change of Platelet Aggregation and TXA_2/PGI_2 Balance before and after PTRA in Dogs

作　　者：梁俊生[1] 贺能树[2] 吴胜勇[2] 刘长宏[2] 李爽[2] 孙丽莎[3] 

机构地区：[1]解放军第二六六医院放射科,河北承德067000 [2]天津医科大学总医院放射科 [3]天津医科大学总医院神经内科

出　　处：《中国中西医结合杂志》1998年第S1期103-105,369-370,共5页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的:研究防治经皮腔内血管成形术(FFA)后再狭窄的药物。方法:20条杂种犬,随机分为3组:川芎嗪组(n=6),阿斯匹林组(n=5)和对照组(n=9)。狭窄术后1～2周肾动脉造影证实形成狭窄,6～8周后行肾动脉成形术(PTRA)。对照组于 PTRA 前及术后4h,两用药组于给药前、PTRA 前及术后4h 分别采集外周静脉血样做血小板聚集率、血栓素B_2(TXB_2)和6-酮.前列腺素F_(1α)(6-keto-PGF_(1α))测定。结果:两用药组给药前后自身比较血小板聚集率、TXB_2均显著降低,6-keto-PGF_(1α)显著升高;而 PTRA 前后自身比较上述指标的变化则无显著性差异。对照组 PTRA 前后自身比较 TXB_2和血小板聚集率显著升高,6-keto-PGF_(1α)则显著降低。组间比较,两用药组 PTRA 前后血小板聚集率、TXB_2均显著低于对照组,6-keto-PGF_(1α)则明显高于对照组,只有术前阿斯匹林组与对照组比较6-keto-PGF_(1α)差异不显著。两用药组组间比较上述指标在 PTRA 前后均无显著性差异。结论:川芎嗪可能是一种有效防治 PTA 后血栓闭塞性再狭窄的药物。Objective:To find drugs for preventing post-angioplasty restenosis.Methods:Twenty model dogs with experimental renal stenosis were divided randomly into 3 groups:the control group,the experiment group A(treated with aspirin)and B(treated with ligustrazine).Percutaneous transluminal renal angioplasty(PTRA)were carried out 6～8 weeks after re- nal artery narrowing operation.Platelet aggregation rate(PAR)and Plasma level of thromboxane B_2(TXB_2)and 6-keto- prostaglandin_(1α)(6KP)were determined in the control group before and 4 hours after PTRA,and for the two experimental groups,before medication,before and 4 hours after PTRA.Results:Self-comparison of the two experiment groups before and after medication showed that PAR and TXB_2 level decreased,and 6KP increased significantly.No significant change of the three indexes was found before and after PTRA in the experiment groups.Self-comparison of tbe control group be- fore and after PTRA showed TXB_2 and PAR increased and 6KP decreased significantly.As for comparison between groups,the results showed that either before or after PTRA,PAR and TXB_2 of the experiment groups were lower than those of the control group,while 6KP was higher in the former two groups than that in the latter one,except that the dif ference of 6KP between experiment group A(aspirin group)and control group before PTRA was insignificant.As com- pared with before PTRA,the three indexes in the two experiment groups after PTRA were not significantly different. Conclusion:Ligustrazine might be one of the effective drugs in preventing thrombosis after PTRA.

关 键 词：血管成形术 川芎嗪 阿斯匹林 血小板聚集 血栓素 B₂ 前列腺素 F_1α 

分 类 号：R285.5[医药卫生—中药学]