益肾活血胶囊抗肾纤维化的实验研究  

Experimental Study of Yishen Huoxue Capsule(益肾活血胶囊)on Renal Fibrosis in Rats

作　　者：乔成林[1] 孙万森[1] 张晓东[1] 马志义[2] 刘锐[1] 

机构地区：[1]西安医科大学第二临床医学院中医科,西安710004 [2]西安医科大学药理教研室

出　　处：《中国中西医结合杂志》1998年第S1期107-109,370,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的:观察益肾活血胶囊对慢性肾功能衰竭(CRF)大鼠肾组织纤维化及血浆内皮素(ET)和肿瘤坏死因子(TNF)的影响。方法:用腺嘌呤灌胃建立大鼠 CRF 模型,予益肾活血胶囊进行防治。结果:治疗组大鼠肾功能明显改善,ET 及 TNF 在血浆中含量明显降低,和病理组比较有显著性差异(P<0.05,P<0.01)。肾组织病理见病理组病损严重,肾小球系膜细胞增生,间质明显纤维化,而治疗组则明显减轻。结论:益肾活血胶囊具有改善肾功能,拮抗血浆 ET 及 TNF,抗肾纤维化的作用。Objective:To observe the effect of Yishen Huoxue Capsule(YSHXC)on renal fibrosis and plasma endothelin(ET) and tumor necrosis factor(TNF)in rats with Chronic renal failure(CRF).Methods:Model of CRF in rats was estab- lished by gastrogavaging with adenine,and YSHXC was given to treat CRF.Results:The renal function was significantly improved and the levels of ET and TNF in plasma decreased in YSHXC treated group,as compared with those of control group(P<0.01 or P<0.05).There was distinct fibrosis of interstitial and construction damage of glomerulus in the control group.Conclusion:The YSHXC could improve renal function,decrease the levels of plasma ET and TNF,and abate renal fibrosis.

关 键 词：益肾活血胶囊 肾纤维化 慢性肾功能衰竭 内皮素 肿瘤坏死因子 腺嘌呤 

分 类 号：R285.5[医药卫生—中药学]