疲劳和紧张应激导致老年前期大鼠自由基损伤及中药五参方防治作用的实验研究  

The Experimental Study on Free Radical Injury Caused by Fatigue and Mental Stress in Presenium Rats and the Protective Effect of Wushen Recipe(五参方)

作　　者：胡利民[1] 徐东琴[1] 范英昌[1] 潘从清[2] 高金亮[2] 

机构地区：[1]天津中医学院,天津300193 [2]天津市中医药研究院

出　　处：《中国中西医结合杂志》1998年第S1期228-229,389,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：天津市科委重点课题

摘　　要：目的:研究社会心理因素对老年前期人群衰老的影响及寻求中医药防治措施。方法:采用较长期的疲劳和紧张应激手段作用于老年前期大鼠,中药治疗组在刺激的同时灌喂五参方煎剂,观察动物血自由基浓度、肝脏 LPO 含量、心肌和脑组织脂褐素含量以及血红细胞 SOD 含量。结果:与同龄空白对照组比较,造模组大鼠血中自由基浓度、肝组织 LPO含量明显升高,心、脑组织脂褐素含量显著增加,红细胞 SOD 含量降低(P<0.05,P<0.01),而中药五参方可明显减轻上述损伤性变化。结论:长期疲劳和紧张应激可加重自由基损伤从而加速衰老,而五参方可通过减轻自由基损伤而达到抗衰老的目的。Objective:To study the influence of mental factors on the presenium of the population and the preventing effect of the Wushen recipe(WSR).Methods:The presenium rats(15 months old)suffered from long-term fatigue and mental stress,were divided into 2 groups,the WSR treated group and the control group.The concentration of blood free radical, the content of liver LPO,lipofuscin in heart and brain,and SOD in RBC were detected.Results:In control group,the free radical concentration of the blood increased,the LPO content in the liver and lipofuscin in the heart and brain in- creased significantly,while the SOD content in RBC decreased(all P<0.01 or P<0.05)when compared with normal rats.In the WSR treated group,all the above items appear reversed changes(P<0.05).Conclusion:The unfavourable mental factor might result in senility by causing free radical injury,the injury could be mitigated by WSR.

关 键 词：疲劳 紧张应激 自由基损伤 五参方 中药防治 

分 类 号：R285.5[医药卫生—中药学]