健骨冲剂对去势大鼠骨质疏松作用的研究  

Experimental Study on Effect of Jiangu Granules(健骨冲剂)on Osteoporosis of Ovariectomized Rats

作　　者：张新民[1] 沈自尹[1] 王文健[1] 陈素珍[1] 陈伟华[1] 段元丽[1] 张卫东[2] 张万年[2] 陈万生[2] 

机构地区：[1]上海医科大学中西医结合研究所,上海200040 [2]第二军医大学药学院

出　　处：《中国中西医结合杂志》1998年第S1期279-281,399,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家教委博士点基金

摘　　要：目的:研究健骨冲剂防治骨质疏松的作用。方法:观察去势大鼠骨密度、生物力学和血雌二醇、甲状旁腺素、降钙素、血钙、骨钙素的变化。结果:健骨冲剂能明显升高去势大鼠全身、腰椎和股骨骨密度;能增加股骨三点弯曲试验的屈服强度、最大载荷和断裂载荷;但不能提高去势大鼠血雌二醇的水平。结论:表明健骨冲剂能防治因雌二醇下降所致的骨质疏松症,但其作用机制不一定通过提高卵巢功能来实现。Objective:To study the effect of Jiangu granules (JGG) on osteoporosis.Methods:Bone mineral density (BMD), biomechanics and E_2,PTH,CT,Ca^(2+),osteocalcin of the blood of ovariectomized rats were observed.Results:JGC could increase the BMD of general skeleton,lumbar vertebrae and femora of the ovariectomized rats and improve the yield strength,maximal load and break load of the femur three-point bending test as well.JGG,however,couldn't increase the serum estradiol level of the ovariectornized rats.Conclusion:JGG could prevent and cure osteoporosis induced by the decrease of estradiol,but its mechanism of action might not rely on ameliorating the function of ovary.

关 键 词：健骨冲剂 去势大鼠 骨质疏松 生物力学 骨密度 

分 类 号：R285.5[医药卫生—中药学]