四君子汤对大鼠三种生物膜流动性的双向调节实验研究  

Study on the Bidirection Regulating Effects of Sijunzi Decoction(四君子汤)on Three Kinds of Biomembrane Fluidity of Rat

作　　者：易崇勤[1] 张家俊[1] 陈文为[1] 堀口贞次郎 江崎 宣久 

机构地区：[1]北京中医药大学中心实验室,北京100029 [2]日本养命酒制造公司中央研究所

出　　处：《中国中西医结合杂志》1998年第S1期305-307,403,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家教委博士点基金; 日本国养命酒制造公司中央研究所的资助

摘　　要：目的:探讨四君子汤煎剂对生物膜流动性的双向调节作用。方法:应用荧光偏振法观察四君子汤对乙醇、胆固醇和大承气汤诱导大鼠(整体)胃粘膜细胞膜、红细胞膜和肝线粒体膜流动性的影响。结果:四君子汤和乙醇、胆固醇、大承气汤均可通过胃肠消化系统吸收,随血液循环输送至周身器官组织细胞部位(包括肝脏细胞内线粒体)发挥不同方式的药效作用。乙醇可诱导大鼠3种生物膜流动性增高,胆固醇和大承气汤可诱导大鼠生物膜流动性降低,而四君子汤煎剂既可降低乙醇诱导的偏高状态膜流动性、又可升高胆固醇和大承气汤诱导的偏低状态膜流动性的作用,且调节趋势是一致的,但与药物剂量没有明显依赖关系。结论:四君子汤煎剂具有增高和降低膜流动性的双向调节作用。Objective:To observe the Sijunzi Decoction (SJZD) in bidirection regulating action on three kinds of biomembrane fluidity.Methods:The regulating effect was studied by fluorescence polarization of DPH labelled.Results:The three in- ducers [ethyl alcohol,cholesterol,Dachengqi decoction(BCQD,大承气汤)] and SJZD could be absorbed by the gastric intestinal system and transported to various tissue cells(including liver mitochondria through blood circulation producing different kinds of pharmacological actions.Ethyl alcohol could increase butcholesterol and DCQD could decrease the fluidi- ty of these three kinds of biomembrane fluidity of rat,while SJZD could both decrease relatively high biomembr and fluidi- ty induced by ethyl alcohol and increase relatively low biomembrane fluidity.Induced by cholesterol and DCQD.The trends to regulate were identical but were dose independent.Conclusion:SJZD could increase and decrease biomembrane fluidity and this effect is bidirection action.

关 键 词：四君子汤 膜流动性 双向调节 

分 类 号：R285.5[医药卫生—中药学]