慢性肾小球疾病血浆和尿血栓调节蛋白的检测及其临床意义  

Clinical significance and assay of plasma and urine thrombomodulin in chronic glomerular disease

作　　者：卢兴国[1] 沈汉超[1] 陈佳兮[1] 刘长生[1] 贾金康[1] 

机构地区：[1]浙江医科大学附属二院,310009

出　　处：《血栓与止血学》1998年第3期105-107,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的:研究慢性肾小球疾病的血浆和尿血栓调节蛋白(PTM和UTM)水平及其临床意义。方法:用ELISA法检测PTM和UTM。结果:105例PTM水平中慢性肾小球肾炎(CGN,35.21±16.06μg/L)高于健康对照组(20.21±7.04μg/L),肾病综合征(NS,71.08±42.41μg/L)和慢性肾功能衰竭(CRF,126.21±60.39μg/L)又依次递增,疾病组之间比较均有显著性差异(P<0.01)。91例UTM结果相反,CGN(253.68±126.67μg/L)明显低于对照组(350.10±108.47μg/L),NS(159.23±86.93μg/L)和CR(93.08±61.82μg/L)又依次递增,各组间比较均有显著性差异(P<0.01)。相关分析发现PTM与BUN、Scr、血和尿β_2MG呈正相关(r=0.5926、0.478、0.5559和0.4409,P均<0.01),与Ccr呈负相关(r=0.6143,P<0.001);UTM与Ccr呈正相关(r=0.6988),与BUN、Scr和血β_2MG呈负相关(r=-0.5039、-0.3888、-0.6020,P均<0.05)。结论慢性肾小球疾病存在PTM和UTM的明显异常,并随疾病的严重度而PTM递增,DTM递减,认为检测TM可作为肾小球血管内皮损伤的敏感指标、并可判断肾功能损害的严重程度。Objective: To study clinical significance and level of plasma and urine thrombomodulin (FTM and UTM) in chronic glomerular disease. Method:PTM and UTM were measured by ELBA.Results:PTM level in 105 patients,chronic glomenlonephritis (CGN,35.21 ± 16.11 ug/L)was significantly increased in comparison with healthy contrast group(20.03±7.77 ug/L,P < 0.001). Nephrotic syndrome(NS,70.96 ± 43.34 ug/L) and chronic renal failure(CRF,125.34 ± 62.15 ug/L) were order of quantily progressively increase,between three disease groups were significant difference ( P < 0.001). UTM level in 91 patients,its results have opposite with PTM.CGN (255.35± 123.26 ug/L)was significantly deceased in comparison with healthy contrast group (350.10±84.35 ug/L,P<0.001),NS(156.73±89.86 ug/L) and CRF (92.47±70.41 ug/L) were order of quantiy decrease progressively, between three disease groups were significant difference ( P < 0.01). FTM level positively correlated with BUN and Scr and serum β2 MG and urine β2 MG level( r = 0.59, P < 0.0001, r = 0.4781,P < 0.001, r = 0.5559, P < 0.05, r = 0.4409, P < 0.01), PTM and Ccr levels were negatively correlated( r = - 0. 6988, P < 0.0001) . UTM and Ccr levels were positively correlated( r = 0.6988, P < 0.0001),and BUN and Scr and serum β2 MG levels were negatively correlated ( r = - 0.5039, P < 0.001, r = -0.3888,P<0.05,r= - 0.6020,P<0.001).Conclusion: Level of PTM and UTM in chronic glomerular disease were markedly unusual, FTM level were in pace with increase of disease serious degree, UTM level were in pare with decrease of disease serious degree. We consider TM assay may as sensitive marker in glomerular endothelial damage, ami detemine the injury serious degree of kidney function.

关 键 词：血浆血栓调节蛋白 尿液血栓调节蛋白 慢性肾功能衰竭 肾病综合征 慢性肾小球肾炎 

分 类 号：R692.6[医药卫生—泌尿科学]