未明原因多部位出血者血小板聚集功能的研究  

Study on Platelet Aggregation of Unknown-Cause Multi-Focal Bleeding

作　　者：沈迪[1] 朱闽[2] 王爱莲[1] 魏文宁[1] 杨锐[1] 刘仲萍[1] 

机构地区：[1]同济医科大学附属协和医院,武汉320022 [2]日本德岛大学医学部

出　　处：《血栓与止血学》1996年第4期145-146,151-188,共4页Chinese Journal of Thrombosis and Hemostasis

摘　　要：本文报道752例未明原因多部位出血患者,特征为易发乌青块、齿龈出血、鼻出血和/或月经过多、眼底出血等;血小板计数和凝血象无异常,而血小板对ADP、花生四烯酸及血小板激活因子诱导的聚集反应有不同的缺陷者,共238例(31.6％)。患者血小板膜糖蛋白水平正常,因而认为本病是一组继发性血小板聚集功能缺陷症。By using platelet aggregation technique, we analyzed 752 blood samples from patients with multiple focal bleedings, were characterized by bruising easily, gum-bleeding, epistaxis, retinal hemorrhage and/of menorrhagia. The results of platelet count, coagulation profiles and membranous glycoproteins are quite normal. We found that 238 cases making a defect of platelet aggregation response to ADP, arachidonic acid or platelet activating factor-induced. The causes of platelet aggregation defect and multiple focal bleedings are unknown. We considered that these patients were a group of acquired platelet aggregation defect.

关 键 词：易发乌青块 多部位出血 血小板聚集缺陷 

分 类 号：R55[医药卫生—血液循环系统疾病]