铝对大鼠纹状体内生长抑素mRNA表达的影响  

EFFECT OF ALUMINUM ON EXPRESSION OF SOMATOSTATIN mRNA IN THE RAT CORPUS STRIATUM

作　　者：董大翠[1] 张艳[1] 熊希凯[1] 陈艳贤[1] 朱清华[1] 

机构地区：[1]同济医科大学人体解剖学教研室,同济医科大学营养卫生学教研室

出　　处：《中国组织化学与细胞化学杂志》1996年第4期385-388,共4页Chinese Journal of Histochemistry and Cytochemistry

基　　金：国家自然科学基金

摘　　要：本实验采用Ｗｉｓｔａｒ大鼠３０只，分为对照组（Ａ组）、硫酸铝钾组（Ｂ组）和硫酸铝钾加柠檬酸组（Ｃ组），分别喂养半年。用原位杂交组织化学和图像分析方法观察大鼠纹状体内生长抑素（Ｓｏｍａｔｏｓｔａｔｉｎ，ＳＳ）ｍＲＮＡ表达的变化。结果表明：给铝组大鼠纹状体内ＳＳｍＲＮＡ表达减少，与对照组的差异有非常显著性意义。In the present study, 30 wistar rats were divided into three groups. Group A was fornormal control, Group B was fed with a solutio containing aluminum potassium sulfate,Group C fed with a solution containing aluminum postassium sulfate and citric acid. All ofthem were fed 6 month respectively. The level changes of somatostatin mRNA expressed inthe corpus striatum were observed by in site hybridization histochemistry and image analysis. The experimental results showed that the expression level of the SSmRNA in the corpusstriatum of the experimental group significantly decreased as compared with the controlgroup.

关 键 词：铝生长抑素mRNA 原位杂交 纹状体 大鼠 

分 类 号：Q959.837.6[生物学—动物学]