Enantiomeric separation of α-phenylethylamine and its analogs by mixed chiral and achiral stationary phase  

作　　者：ZHOU, Liang-Mo LIU, Xue-Liang LI, Zhong-Sheng WANG, Qing-Hai ZHU, Dao-QianDalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116012, ChinaHU, Dong-HongDepartment of Chemistry, Fujian Quanzhou Teacher’s College, Quanzhou, Fujian 362000, China 

出　　处：《Chinese Journal of Chemistry》1996年第4期348-353,共6页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China.

摘　　要：A mixed stationary phase of modified β-cyclodextrin, 2,6-di-O-butyl-3-O-butyryl-β-cyclodextrin (phase A), and SE-54 (phase B) was used for enantiomeric separation of α-phenylethylami-ne, o,m,p-methyl and o,m,p-methoxy-substituted analogs. The composition of mixed phase was selected by comparison of each calculated amin(= (γm,i+1)/(γm,i))> the relative retention values of the most adjacent peaks, and γm,last, the relative retention values of the last eluting peak at each preselected ratio. Values of γm,i,α calculated by derived equations were in good agreement with the experimental results obtained with two specified mixed phases. All solutes investigated were almost baseline separated at a predicted composition of phase A and phase B in a single run within 18 minutes.A mixed stationary phase of modified β-cyclodextrin, 2,6-di-O-butyl-3-O-butyryl-β-cyclodextrin (phase A), and SE-54 (phase B) was used for enantiomeric separation of α-phenylethylami-ne, o,m,p-methyl and o,m,p-methoxy-substituted analogs. The composition of mixed phase was selected by comparison of each calculated amin(= (γm,i+1)/(γm,i))> the relative retention values of the most adjacent peaks, and γm,last, the relative retention values of the last eluting peak at each preselected ratio. Values of γm,i,α calculated by derived equations were in good agreement with the experimental results obtained with two specified mixed phases. All solutes investigated were almost baseline separated at a predicted composition of phase A and phase B in a single run within 18 minutes.

关 键 词：Modified cyclodextrin enantiomeric separation α-phenylethylamine and its analogs 

分 类 号：O658[理学—分析化学]