PREPARATION　AND　CHARACTERIZATION　OF　A　NEW　COENZYME　B_（12）　ANALOGUE　CONTAINING　2＇，3＇－　DIDEOXYURIDINE  

作　　者：Bao Hua ZHU Hong YAN Lai Bin LUO Ze Hua LIU Hui Lan CHEN(Department of Chemistru,Coordination Chemistry Institute and Coordination Chemistry State Key Laboratory,Nanjing University,Nanjing,210093) 

出　　处：《Chinese Chemical Letters》1996年第6期503-504,共2页中国化学快报（英文版）

摘　　要：Anew kind of coenzyme B12 analogue 2',3' ,5' -trideoxyuridinyl-cobalamin(ddUCbl) wasfirst synthesized by an improved method in which 5'-O-toluenesulfonyl-2',3'-dideoxyuridilne wasfirst transormed into 5'-iodo-2',3'-dideoxyuridine and then reacted with reducdhydroxocobalamin. The new analogue was characterized by UV-yis and1 HNMR spectroscopyAnew kind of coenzyme B12 analogue 2',3' ,5' -trideoxyuridinyl-cobalamin(ddUCbl) wasfirst synthesized by an improved method in which 5'-O-toluenesulfonyl-2',3'-dideoxyuridilne wasfirst transormed into 5'-iodo-2',3'-dideoxyuridine and then reacted with reducdhydroxocobalamin. The new analogue was characterized by UV-yis and1 HNMR spectroscopy

分 类 号：O62[理学—有机化学]