k阿片受体激动剂抑制大鼠吗啡戒断症状的发生  

SUPPRESSION OF MORPHINE ABSTINENCE SYNDROME BY U─50,488H, A K─OPIOID RECEPTOR AGONIST IN RATS

作　　者：吴鎏桢[1] 崔彩莲[1] 韩济生[1] 

机构地区：[1]北京医科大学神经科学研究中心

出　　处：《Neuroscience Bulletin》1995年第4期168-172,共5页神经科学通报（英文版）

摘　　要：用多次注射吗啡的方法造成大鼠对吗啡的依赖，给大鼠脊髓蛛网下腔（ｉ．ｔ．）注射ｋ（ｋａｐｐａ）阿片受体激动剂Ｕ－５０，４８８Ｈ（２．５、５、１０μｌ）或ｋ受体拮抗剂ｎｏｒ—ＢＮＩ（１．２５、２．５、５μｌ／１０μｌ）后，用纳洛酮（ＮＸ）催瘾，观察并记录四种戒断症状：湿科（ｗｅｔｓｈａｋｅｓ）、咬牙（ｔｅｅｔｈｃｈａｔｔｅｒｉｎｇ）、逃跑企图（ｅｓｃａｐｅａｔｔｅｍｐｔｓ）、体重丢失（ｗｅｉｇｈｔｌｏｓｅ）。结果表明Ｕ—５０，４８８Ｈ可以明显减轻湿抖、咬牙和逃跑企图，并呈量效关系；ｎｏｒ—ＢＮＩ则使温抖、咬牙和体重丢失三种症状明显加重，也呈量效关系。上述结果表明，激活脊髓。受体对吗啡戒断症状有明显的抑制作用，阻断Ｋ受体则加重戒断症状。Rats were made dependence on morphine by multiple injections. Intrathecal administration (i.t.) of U─50, 488H (2.5, 5, 10μg/10μl), a K─opioid receptor agonist or nor─BNI (1.25, 2.5, 5μg/10μl), aK─opioid receptor antagonist followed by naloxone challenge (0.5mg/kg, i.p.) and the withdrawal syndrome was scored for a period of 60─min. U─50, 488H produced a dose─dependent suppression of wet shakes,teeth chattering and escape attempts, whereas nor─BNI produced a dose─dependent increase in wet shakes,teeth chattering and weight loss. The results indicate that activation of K─opioid receptors in spinal cord suppresses morphine withdrawal syndrome, blockage of the receptors increases the syndrome. As 100Hzelectroacupuncture (EA) or 100Hz transcutaneous electrical nerve stimulation (TENS) has been shown to accelerate the release of dynorphin (K agonist) in spinal cord, the nudings of the present study seem to provide new evidence for clinical use of 100Hz EA or TENS for treating morphine withdrawal syndrome.

关 键 词：吗啡依赖 K阿片受体 戒断症状 U-50 488H nor-BNI 

分 类 号：R338.2[医药卫生—人体生理学]