冬虫夏草对小鼠骨髓和小肠上皮急性损伤防护效应的研究  

THE RADIATION PROTECTIVE EFFECTS OF CHINESE DRUG CORDYCEPS SINESIS ON MOUSE ACUTE NORMAL TISSUE RADIATION DAMAGE

作　　者：杨伟志[1] 沈瑜[1] 王京红[1] 董秀月[1] 

机构地区：[1]中国医学科学院肿瘤医院

出　　处：《中华放射肿瘤学杂志》1995年第3期33-35,共3页Chinese Journal of Radiation Oncology

摘　　要：观察冬虫夏草发酵菌丝（ＤＣＸＣ）对小鼠受Ｘ线照射后骨髓及小肠的防护作用。实验结果显示：（１）照射前服用ＤＣＸＣ的各照射剂量组，小鼠骨髓干细胞的存活数均高于单纯照射组，防护系数为１．６７；（２）昆明小鼠无论照射前给药或照前、照后连续给药，对小肠隐窝干细胞均有一定保护作用。表明，ＤＣＸＣ对辐射诱发的小鼠骨髓及小肠急性损伤具有较好防护效果。The radiation protective effect of Cordyceps Sinesis on bone marrow and intestion acute radiation damage were studied by measuring the number of colony-forming unit in spleen and number of survival crypt stem cells. The experimental results shows that:1) The mice given Cordyceps Sinesis for 10 days before irradiation, the number of survival bone marrow stem cells is higher than X-ray irradiation only. The dose modifying factor DMF is 1 67. 2) The mice used drug no matter whether the Cordyceps Sinesis was giver before or after irradiation or both, are with a higher survival crypt numbers. These suggest that Cordyceps Sinesis have a useful protective effects to bone marrow and intestine acute radiation damage.

关 键 词：骨髓放射损伤 小肠放射损伤 放射防护剂 

分 类 号：R285.5[医药卫生—中药学]