冠心病患者红细胞胰岛素受体的研究  

STUDIES ON ERYTHROCYTE INSULIN RECEPTOR OF PATIENTS WITH CORONARY HEART DISEASE

作　　者：严毓勤[1] 徐济民[1] 朱菊红[1] 吴万龄[1] 

机构地区：[1]上海第二医科大学附属第九人民医院内科

出　　处：《中国循环杂志》1990年第6期430-432,507-508,共5页Chinese Circulation Journal

摘　　要：我们测定了30例冠心病患者和29名对照者红细胞胰岛素受体,发现冠心病组胰岛素受体数显著低于对照组,111.3±25.1对198.6±24.9 受体/RBC,而受体亲和力的代偿性升高,使胰岛素结合率维持正常,圆满地解释了冠心病患者的耐糖降低、胰岛素反应增高现象。Erythrocyte insulin binding studies were performed in 30 patients with coronary heart disease(CHD) and 29 healthy subjects. The results showed that patients with CHD had decreased concentration of insulin receptors on ery- throcyte as compared with controls, 111.3±25.1 versus 198.6±24.9 sites/RBC, and increased receptor affinity resulting in insulin binding (B/T)within normal range. These findings may explain the phenomena found by a number of researchers that a decreased glucose tolerance and an elevated insulin responce to oral glucose are present in patients with CHD, Furthermore, the relationship of plasma liplds to serum insulin and insulin receptor was investigated. Among the controls, insulin receptor in male and female was also evaluated. A hypothesis about the pathogenesis of atherosclerosis was proposed from the results of the present studies.

关 键 词：红细胞胰岛素受体 冠心病 

分 类 号：R54[医药卫生—心血管疾病]