肺心病患者血栓素A_2—前列环素平衡的研究  

Study on TXA_2-PGI_2 balanee in patients with cor pulmonale

作　　者：鲍文华[1] 张伦[1] 任淑兰[1] 李秀芝[1] 倪淑艳[1] 

机构地区：[1]佳木斯医学院附属医院呼吸内科

出　　处：《黑龙江医药科学》1990年第1期15-18,88,共5页Heilongjiang Medicine and Pharmacy

摘　　要：本文用放免法测定了29例肺心病患者血浆TXB₂6—酮—PGF₁^α水平的变化,同时对其平均肺动脉压及血气进行了测定。结果表明:肺心病急性加重期TXB₂升高,6—酮—PGF₁^α下降,TXB₂/6—酮—PGF₁^α比值升高。缓解期,TXB₂下降,6—酮—PGF₁^α上升,TXB₂/6—酮—PGF₁^α下降,但均末达到正常水平。相关分析表明:ppA与TXB₂正相关,与6—酮—PGF₁^α负相关、与TXB₂6—酮-PGF₁^α正相关;PaO₂与6—酮—PGF₁^α正相关与TXB₂6-酮-PGF₁^α负相关。提示肺心病存在TXA₂-PGI₂平衡失调,且此平衡失调在低氧性肺血管收缩中起重要作用。The plasma concentration of TXB_2, 6-Keto-PGF_1α was measured by RIA in 29 patients with cor pulmonale and 17 health person. The result showed that: ①TXB_2 was elevated, 6-Keto-PGF_1α reduced and ratio of TXB_2 to 6-Keto-PGF_1a elevated in acute stages of cor pulmonale; after treatment, TXB_1 was lowered, 6-Keto-PGF_1α increased and the ratio reduced, but they all didn't reach the control level. ②the correlation study indicated that mean pulmonary arteriol pressure (Ppa) was correlated with TXB_2 (R=0.685,p<0.01), 6-Keto-PGF_1α(R=-0.827, p<0.01), and the ratio of TXB_2 to 6-Keto-PGF_1α(R=0.773, p<0.01). ③PaO_2 was correlated with 6-Keto-PGF_1α(R=0.555, p<0.01)and the ratio of TXB_2 to 6-Keto-PGF_1α(R=0.639, p<0.01). It isconcluded that there is TXA_2—PGI_2 imbalance in the patients with chronic cor pulmonale and the TXA_2—PGI_2 imbalance play an important role in the hypoxic pulmonary vasocontriction.

关 键 词：肺心病 TXA₂ PGI₂ 

分 类 号：R9[医药卫生—药学]