芳酸偶氮吡唑啉酮及其麻黄碱盐的合成  

SYNTHESIS OF ACIDIC 4-ARYLAZO-2-PYRAZOLIN-5-ONES AND ITS EPHEDRA ALKALOIDS SALTS

作　　者：綦聚鳌 张清德[1] 冯文化 陈建军 王洪权 刘笑融[1] 吴冬梅[1] 

机构地区：[1]内蒙古医学院药学系

出　　处：《化学研究与应用》1989年第1期93-96,共4页Chemical Research and Application

摘　　要：近期报道了吡唑啉酮衍生物与稀土金属的络合作用。关于4-芳基偶氮吡唑啉酮与过渡金属络合的作用已有报道,但与稀土金属络合的文献不多。根据英国药典,麻黄碱与铜离子络合呈色而作为其鉴定方法,本文制备了麻黄碱类与芳酸偶氮吡唑啉酮形成的盐,以备研究它们的络合作用。在合成的5种吡唑啉酮衍生物中。A series of 4-phenylazo-2-pyrazolin-5-ones having a carbo(?)l or arsono group in benzene nucleus were prepared by two methods: (1) coupling of the co(?)responding diazotized aromatic amines with 2-pyrazolin-5-ones, (2) the diazonium sals of aromtie amines reacting with acetoacetic estet and then cyclizing with phenylhydrazine to form 4-arylazo-2-pyrazolin—5—ones. The acidic azo dyes were allowed to react with Ephedra alkaloids to give salts. As we predicted some of them were found to be expected complexing reagents for rare earth elements.

关 键 词：4-arylazo-3-methyl-1-phenyl-2-pyrazolia-3-one EPHEDRINES complex rare earth element. 

分 类 号：O6[理学—化学]