沪191株麻疹减毒活疫苗初免后16年的血清流行病效果研究  

Study on the Sero-Epidemiologic Efficacy of Shanghai 191 Measles Live Vaccine after 16 Years since Primary Immunization

作　　者：陈志慧[1] 任西根 杨惠英[3] 吴霆[4] 徐闻青[1] 韩淼森 胡逢蛟[3] 徐宝祥[4] 陈惠菊 褚宝林 

机构地区：[1]卫生部上海生物制品研究所 [2]浙江省象山县卫生防疫站 [3]浙江省宁波市卫生防疫站 [4]浙江省卫生防疫站 [5]浙江省象山县卫生防

出　　处：《中国生物制品学杂志》1989年第2期5-9,共5页Chinese Journal of Biologicals

摘　　要：在象山县高塘岛乡,我们连续16年对273名沪191株麻疹减毒活疫苗初免成功者进行了抗体持久性观察。HI抗体阳性率为83.2%,GMT为3.6,表明该疫苗具有良好的免疫原性。1988车观察基地内发生自然麻疹,34名观察对象接触后,有2名HI抗体<1:2者发生显性感染,32名HI抗体为<1:2～1:8者发生隐性感染,初步说明了抗体水平与感染类型的关系。This article reports the study of the duration of immunity induced by Shanghai 191 measles live vaccine in Gao Tang Island of Xiangshan County. 273 children immunized in 1973 were observed over 16 consecutive years. The positive rate of measles HI antibody was 83.2% and GMT was 1:3.6 in the 16th year.In an outbreak of natural measles in Gao Tang Island in 1988,34 vaccinees were exposed by patients.Two children who had been vaccinated in 1973 End 1978 became ill with measles (their HI antibody<l:2 in 1987), but 32 children (HI antibody<l:2~1:8 in 1987) were inapparent infection. The results suggested that this vaccine has adequately iminunogenic.

关 键 词：麻疹疫苗 免疫持久性 流行病学效果 

分 类 号：R977[医药卫生—药品]