左旋咪唑及吡喹酮对鼠体内广州管圆线虫幼虫杀灭效果的研究  

LARVICIDAL EFFECTS OF LEVAMISOLE AND PRAZIOUANTEL ON ANGIOSTRONGYLUS CANTONENSIS IN RATS

作　　者：何竞智[1] 

机构地区：[1]广东医药学院寄生虫学教研室

出　　处：《广东药学院学报》1989年第1期18-21,共4页Academic Journal of Guangdong College of Pharmacy

摘　　要：本文报道感染50条和100条广州管圆线虫幼虫的大白鼠,在感染后第6天开始用左旋咪唑及吡喹酮口服治疗,前者给10mg/kg/日,连用3天和6天,后者给25mg/kg/日,连用6天,每组大白鼠在感染后第14,15、21、22天解剖,从鼠脑收集虫体数,与对照组比较,治疗组收集虫数明显少,治疗3天和6天虫减少率分别为90～96％和99～100％,提示:左旋咪唑有高的杀幼虫效果。连用6天优于连用3天,两者有显著差异,(U=8.30,P<0.001)。吡喹酮治疗6天,虫减少率为65～97％,也有良好的杀虫效果,但不如左旋眯唑好,两者比较,有显著差异,(U=7.45P<0.001)。Rats were infected with 50 and 100 third stage larvae of Angio- strongylus cantonensis and treated orally with levamisole and praziquantel in dosages of 10 mg/kg/day and 25 mg/kg/day for 3 and 6 consecutive days respectively on the 6th day of post-infection. The rats in each group were killed on the 14th, 15th, 21th and 22th day of post-infection and the brains examined for parasites. Worms were recovered from the brains of all rats treated, but the recoveries from treated rats were significantly lower than those from the control groups. The results indicate that levamisole has high- ly larvicidal effect on Angiostrongylus cantonensis for 3 and 6 consecutive days. Worm reduction rate was 90-96% and 99.8-100% respectively. But effect of treatment for 6 consecutive days is better than that for 3 consecutive days. The medicinal effect between groups shows significant difference (U=8.30, P<0.001). Treatment with praziquantel for 6 consecutive days on infected rats is also effective. Worm reduction rate was 65-97%. But larvicidal effect of levamisole was better than that of praziquantel. The medicinal effect bet- ween groups has significant difference (U=7.45, P<0.001).

关 键 词：左旋咪唑 吡喹酮 广州管圆线虫 

分 类 号：R9[医药卫生—药学]