麻风病人血中抗神经抗体的初步研究  

Preliminary Study on Anti-Nerve Antibody in the Sera of Leprosy Patients

作　　者：黄林邦[1] 张志渊[1] 

机构地区：[1]赣南医学院皮肤病理研究室

出　　处：《中国麻风皮肤病杂志》1989年第1期7-10,共4页China Journal of Leprosy and Skin Diseases

摘　　要：对36例麻风患者用间接酶标免疫组织化学法,检测了循环抗神经抗体。10名正常成人为对照组,结果麻风病人的检出率为83.33％。用酶标羊抗人IgG单克隆抗体可使神经组织着色。抗神经抗体在神经组织切片中主要结合在神经纤维的髓鞘细胞膜和神经轴索上。未经治疗和短期用药者几乎都可检出,这可能与DDS对病人IgG浓度的影响有关。10例正常人血清在1:50和1:100的稀释度时,呈弱阳性。本文结果表明此方法,可作为临床早期诊断、判断神经受损程度和估计病人预后的一项参考指标。The circujar anti-nerve antibody was examined with indirect enzyme linked immunohistochemical assay in 36 cases of leprosy with normal control of 10 healthy persons. The result shows that the positivity is 83.33% in the leprosy patients. The enzyme linked monoclonal antibody of the goat anti-human IgG is able to put colour on the nerve tissue. In the sections of the nerve the antinerve anti-body is mainly combined with the mem-branes of myelin sheath cells and the nerve axons.The weak positivity may be seen in the sera of 10 healthy controls while the dilution titer is in 1:50 or 1:100. The authors consider this method could be used to early diagnose leprosy, judge the degree of the nerve injury and assess the prognosis of the pailents as a reference index.

关 键 词：麻风病人 麻风患者 抗体滴度 酶标免疫 组织化学法 IgG 单克隆抗体 用药者 皮肤病防治院 受损程度 

分 类 号：R75[医药卫生—皮肤病学与性病学]