党参及其有效成分抗胃粘膜损伤作用与机制研究 Ⅱ、党参部位提取物抗胃粘膜损伤作用观察  

studies on the Pharmacological Effects and Mechanisms of Codonopsis Pilosula (CP) and Its Efficacious Chemical Ingredients on Preventing the Gastric Mucosal Damage of Rats I . The Effects of the Extracts of CP

作　　者：刘良[1] 王建华[2] 胡燕[2] 侯宁[2] 陈嘉文[2] 

机构地区：[1]广州中医学院 [2]广州中医学院脾胃研究室

出　　处：《中药药理与临床》1989年第3期11-14,共4页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：本文报告了党参抗胃粘膜损伤作用的有效部位的初步研究结果。从党参酒提取物中分离的水溶性部分(部位Ⅶ)对无水乙醇、0.6NHCl和0.2NNaOH引起的大鼠胃粘膜损伤具有良好的保护作用,酯溶性部分未见上述作用。故认为部位Ⅶ可能是党参抗胃粘膜损伤的主要有效部位。其抗损伤作用机制可能与影响胃粘膜内PG合成和或释放有关。This paper has reported that the pharmacological effects of the extract of CP on preventing the gastric mucosal damage in rats. It was confirmed that the water soluble section (section VII) which was extracted from the alcohol extract of CP had a significant protective effect cn gastric mucosal damage caused by alcohol, 0.6 N HC1 and 0.2N NaOH, but no marked protective effect was revealed by administering the ester soluble section of CP. Therefore, the water soluble section (section VII) is probably a effective section of CP on protecting gastric mucosal damage. The pharmacological effective pathways are probably related to the synthesis and/or release of prostagrandins in gastric mucosa.

关 键 词：党参部位Ⅰ 党参部位Ⅶ 胃粘膜损伤 溃疡指数 

分 类 号：R28[医药卫生—中药学]