实验性冠状动脉血栓形成致急性心肌梗塞动物模型的研究  

EXPERIMENTAL STUDY ON MODEL OF CORONARY ARTERIAL THROMBOSIS AND ACUTE MYOCARDIAL INFARCTION IN DOG

作　　者：方唯一[1] 赵华月[1] 张杨刚 

机构地区：[1]同济医科大学附属同济医院内科 [2]同济医院放免室

出　　处：《中国循环杂志》1989年第3期262-264,300,共4页Chinese Circulation Journal

摘　　要：本文采用损伤犬冠脉内皮、放置铜丝于冠脉腔内和使局部冠脉狭窄形成湍流的方法,建立了一种能在15～30分钟内在冠脉腔内形成血栓,并很快造成心肌梗塞的动物模型。结果显示。15分钟左右心电图ST段开始抬高、血小板聚集率逐渐升高、血浆TXB_2迅速增加而6-酮-PGF_(1a)升高不明显、血小板内cAMP和cGMP均升高、组织学显示冠脉血栓形成和心肌缺血坏死。本方法对研究冠脉血栓形成、抗血小板聚集和抗血栓素合成药对血栓性心肌梗塞疗效及药理学的研究及溶栓治疗的研究是一种有价值的模型。A model of experimental coronary arterial thrombosis and myocardial infarction in dog was produced within 15～30main. by mechanical injury, of the coronary endothelium with a copper wire (1.5cm long) inserted into the lumen and local stenosis of the coronary vessel. The results showed that ST segment of ECG began to elevate at 15 min. after the operation, platelet aggregation rate and the level of plasma TXB_2 increased rapidly, the concentration of plasma 6-Keto-PGF_1α did not change, the level of platelet cGMP rose continuously, however, the level of platelet cAMP rose only at 60min. Histological results showed coronary arterial thrombosis and myocardial necrosis.

关 键 词：冠状动脉血栓 急性心肌梗塞 

分 类 号：R54[医药卫生—心血管疾病]