丁基氟脲嘧啶β-D-半乳吡喃糖苷的合成  

SYNTHESIS OF β-D-GALACTOPYRANOSIDES OF BUTYL FLUOROURACIL

作　　者：孙昌俊[1] 陈再成[1] 黄明湖[2] 李吉海[1] 谢新记[1] 高建军[1] 

机构地区：[1]山东大学化学系 [2]山东省医学科学院

出　　处：《山东大学学报（理学版）》1989年第4期122-125,共4页Journal of Shandong University(Natural Science)

摘　　要：以银盐法合成了2-O-正丁基-4-O-(2′,3′,4′,6′-四-O-乙酰基-β-D-半乳吡喃糖基)-5-氟脲嘧啶4,4在甲醇中氨解后得到2-O-正丁基-4-O-(β-D-半乳吡喃糖基)-5-氟脲嘧啶5。The acetyl galactopyranoside,2-O-n-butyl-4-O-(2′,3′,4′,6′-tetra-O- acetyl-β-D-galactopyranosyl)-5-fluorouracil 4 was synthesized from 2,3,4,6- tetra-O-acetyl-l-bromo-l-deoxy-a-D-galactopyranose Ⅰ and 2-O-n-butyl-5- fluorouracil silver 3 in xylene.Then 4 was treated with ammonia to obtain 2- O-n-butyl1-4-O-(β-D-galactopyranosyl)-5-fluorouracil 5.These compounds (4 and 5)have not been reported in literature.Their structures were confirmed by elemental analysis,IR and ~1HNMR spectroscopy,as well as by mass spectrometer.

关 键 词：半乳糖苷 丁基氟脲嘧啶 抗肿瘤药物 

分 类 号：N[自然科学总论]