Studies on the method of total synthesis of koumine——Ⅰ.4-Substituted 1,2-dihydropyridine derivatives and their function as a conjugated diene in Diels-Alder reaction  

作　　者：WANG Zhi-Qin LUO Yi-Lin Shanghai Institute of Organic Chemistry,Academia Sinica,Shanghai 

出　　处：《Acta Chimica Sinica English Edition》1989年第3期270-276,共1页

摘　　要：A route to the total synthesis of koumine has been suggested.Five 4-substituted 1,2- dihydropyridine derivatives,which are supposed to be a conjugated diene of Diels-Alder reaction to produce the isoquinuclidine ring of koumine,have been synthesized.Only two of them were found to be able to undergo the Diels-Alder reaction.The stereochemistry of the reaction product has also been examined.A route to the total synthesis of koumine has been suggested.Five 4-substituted 1,2- dihydropyridine derivatives,which are supposed to be a conjugated diene of Diels-Alder reaction to produce the isoquinuclidine ring of koumine,have been synthesized.Only two of them were found to be able to undergo the Diels-Alder reaction.The stereochemistry of the reaction product has also been examined.

关 键 词：Studies on the method of total synthesis of koumine 

分 类 号：O6[理学—化学]