头孢噻甲羧肟对严重下呼吸道感染的临床疗效观察  

THE CLINICAL EFFECT OF CEFTAZIDIME IN SERIOUS LOWER RESPIRATORY INFECTION

作　　者：高立[1] 孙春华[1] 凡永固 于洪滨 靳立英 雷玉晶[1] 马娟[1] 付得兴[1] 

机构地区：[1]北京医院

出　　处：《中国临床药理学杂志》1989年第S1期60-66,共7页The Chinese Journal of Clinical Pharmacology

摘　　要：用头孢噻甲羧肟ceftazidime(fortum)CAZ)治疗用其它抗菌素无效的严重下呼吸道感染10例(其中7例为绿脓杆菌感染)治愈5例,显效3例、有效1例、总有效9例.对G^-菌(尤其是绿脓杆菌)显示了强大的抗感染效果.在使用中未发现明显不良反应.对6例健康志愿者静脉滴注单剂量CAZ 2g后进行了药代动力学的测定,其半衰期为1.87h.分布容量为18.35L/kg,清除率为117.27g/L/min.根据投药后7h的血药浓度尚能抑制绝大多数的细菌(甚至金黄色葡萄球菌亦能被抑制)及Eagl氏的理论,作者认为每12h静脉投药2g是合理的.Ten Patients with serious lower respiratory infection including 7pseudomonas aeruginosa infection with no response to other antibiotics got satisfactoriesto ceftazidime. 5 of the 10 patiente were cured. 3 clinically cured, 1 improved, and 1unassessable.No serlous toxicity and adverse effects were observed except 1 case of hypersensitive reac- tion.The pharmacokinetics of after inftazidime of in-travenous infusion or 2g in 6 healthyvolunteers were meassured. The half life was 1.87h, volume of distributidn 18.35 l / kg,rate of clearance 117.27 mg / l.min.Accord-ing to Eagl's theory and the serum cefatzidimeconcentration 7 hours after adminstration in 6 healthy volunteers most bacteria, evenstaphylococcus aureus, can be inhibited; so, the administration of 2g q 12 h. iv ofceftazidime is reasonable.

关 键 词：头孢噻甲羧肟 药物动力学 下呼吸道感染 临床疗效 

分 类 号：R969[医药卫生—药理学]