肺癌患者血清中免疫学性质改变的CuZn—超氧化物歧化酶的变化  

The serum immunologic-changed CuZn-containing superoxinant nismutase in lung cancer patients

作　　者：周东[1] 田亚平[1] 何长清[1] 沈文梅[1] 李峻亨[1] 

机构地区：[1]中国人民解放军军医进修学院呼吸科

出　　处：《解放军医学院学报》1989年第1期32-34,共3页Academic Journal of Chinese PLA Medical School

摘　　要：近年来越氧化物歧化酶(Superoxide dismutase·SOD)与癌症的关系受到国内外学者的重视。1987年方允中、刘智峰报道了抗牛Cuzn—SOD的抗血清与肿瘤患者血中CuZn—SOD出现强抗原抗体反应的新发现,提出了肿瘤患者血中一部分CuZn—SOD的免疫学性质可能发生了变化。The serum level of immunologic-changed CuZn-containing superoxidant dismutase (GuZn-SOD) was determined in 41 patients with lung cancer and compared with that in 22 normal persons and 11 cases of benign pulmonary disease.The following results were obtained: the X±SD in lung cancer was 16.20±5.41ng/ml; that in benign pulmonary disease was 9.32±4.29ng/ml; and that in normal adults was 7.22±3.72ng/ ml. The mean of the activity of serum immunologic-changed CuZn-SOD in patients with lung cancer was significantly higher (P<0.001). The serum immunologic-changed CuZn-SOD level (11.98ng/ml) may be served as a positive, finding for the presence of lung cancer, the positive rates being 78%,18%,4.5% in the three groups respectively.In the light of the above findings, it may be suggested that the determination of the activity of serum immunologic-changed CuZn-SOD is helpful in the diagnosis of lung cancer.

关 键 词：肺癌患者血清 CuZn 免疫学 抗原抗体反应 肺部良性疾病 允中 肺癌标记物 小细胞癌 癌胚抗原 发光免疫分析 

分 类 号：R82[医药卫生—临床医学]