小量阿斯匹林治疗老年人缺血性脑血管病的临床、血药浓度及血小板聚集力监测  

The effect of low dosager acetylsalicylic acid (ASA) on old patients with ischemic cerebrovascular disease——A study of the clinic effect, blood drug concentration and inhibition of platelet aggregation

作　　者：马志忠[1] 罗毅[1] 汤洪川[1] 卢文甫[1] 于慧玲[1] 张平[1] 蔡乾铭 陈秀兰[2] 王红[2] 李茨芬 李瑞友[3] 殷宗健[3] 李晖[4] 

机构地区：[1]中国人民解放军军医进修学院保健办神经内科 [2]中国人民解放军军医进修学院临床药研室 [3]中国人民解放军军医进修学院血液病化验室 [4]中国人民解放军军医进修学院医学统计研究室

出　　处：《解放军医学院学报》1989年第2期124-127,共4页Academic Journal of Chinese PLA Medical School

摘　　要：用阿斯匹林(ASA)治疗缺血性脑血管病疗效肯定。但以前应用的剂量较大,现在较一致认为小剂量既能取得满意的效果。而用小剂量ASA治疗老年人(60岁以上)的缺血性脑血管病尚未见报道。本文报道30例,肠溶ASA0.3克隔日1次18例;普通ASA0.1g每日1次12例,治疗效果满意。且未发现副反应。26例(患者12例,正常人14名)进行了血药浓度监测。结果服药后2—4小时血药浓度达高峰,24小时基本排完。16例(10例患者,6名正常人)动态观察了血小板聚集力的变化。结果示ASA对血小板聚集力有明显抑制作用,且一次用药作用持续时间较久,服药后7天才基本恢复至服药前水平,提示用药时间间隔可更长或剂量可更小。通过对血小板聚集力的监测,ASA的疗效从理论上亦得到了证实。Thirty old men aged 62-93 years (mean 69.23 years) suffering from ischemic erebrovascular disease were treated with oral low dosage ASA, 100mg ordinary ASA daily or 00mg nteric-coated ASA every other day. Their therapeutic effects were satisfactory. It has been ound that the blood ASA concentration, as determined in 12 patients and 14 mormal subjects, eached its peak level 2-4 hourse after ingestion and gradually faded away 24 hourse after dministration. The effects of inhibition on platelet aggregation were tested in 10 patients nd ormal subjects. The result showed that a single dose of ASA is capable to produce sustained nhibition on platelet aggregation up to 7 days. These findings indicate that this satisfactory ntiplatelet aggregation effect may be abtained in the management of ischemic cerebro vascular isease or prevention of stroke in the elderly.

关 键 词：阿斯匹林 血药浓度 血小板 凝集 脑缺血 

分 类 号：R82[医药卫生—临床医学]