屏障环境常用消毒剂对实验动物皮肤作用的毒性研究  

Skin Toxicity Effects of Common Disinfectants of Barrier Environment on Laboratory Animals

作　　者：周文伟[1] 傅颖[1] 施张奎[1] 萨晓婴[1] 

机构地区：[1]浙江省医学科学院,杭州310013

出　　处：《医学研究杂志》2009年第4期103-105,共3页Journal of Medical Research

摘　　要：目的观察0.2%含量的次氯酸钠、2%含量的过氧乙酸、2%含量的戊二醛溶液和0.2%含量的过氧乙酸,对实验动物和工作人员破损皮肤短期内接触所产生的毒性作用。方法利用上述消毒剂对豚鼠进行人为皮肤破损毒性实验,观察豚鼠全身中毒表现和死亡情况。结果2%过氧乙酸给药后出现轻度水肿,3天后症状消失;2%戊二醛给药后出现红肿、出血点,4天后出现脱皮现象,5天红肿消失,并伴有棕黄色着色性;0.2%次氯酸钠和0.2%过氧乙酸均未出现毒性反应。结论2%过氧乙酸、2%戊二醛对动物和工作人员有毒性作用。Objective To observe the toxic reaction caused by short time contact with some common disinfectants such as 0.2% sodium hypochlorite,2% acetic acid and 2% glutaraldehyde and 0.2% acetic acid, through wounded skin of laboratory animals and laborers. Methods Toxicity experiments of these disinfectants by artificial skin wound were carried on in guinea pigs ,and the poisoning performance and the death situation of guinea pigs were observed. Results Light edema was caused by using 2% acetic acid,and the symptom disappeared after 3 days ; it appeared the symptom of red bump and hemorrhagic spots after use 2% glutaraldehyde , and ecdysis occured after 4days, the red bump disappeared after 5 days with a brownish discoloration left; it didn＇t appear any toxic reaction by using 0.2% sodium hypoehlorite and 0.2% acetic acid. Conclusion There was toxic effect of 2% acetic acid and 2% glutaraldehyde to animals and laborers.

关 键 词：消毒剂 毒性 实验动物 临床研究 

分 类 号：R979.7[医药卫生—药品] R-332[医药卫生—药学]