急性鼻炎患者鼻腔微生物的分布及与呼吸道感染的相关性研究  

Microbic distribution of acute rhinitis patients＇ nasal cavity and dependability research of respiratory infection

作　　者：周序玲[1] 隆琰[1] 林春招[1] 江远仕[1] 陆学东[1] 杨衬[1] 黄烈[1] 曾火太 陈小可[1] 李梅[1] 

机构地区：[1]深圳市福田区人民医院五官科,广东省深圳518033

出　　处：《中国基层医药》2009年第3期437-438,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省深圳市科技计划项目（200803150）

摘　　要：目的 探讨急性鼻炎患者鼻腔微生物的分布特点及与呼吸道感染的相关性。方法436例急性鼻炎患者，根据是否伴有呼吸道感染而随机分为感染组（314例）和非感染组（122例）。取鼻液进行鼻腔微生物检测，同时检测血清白细胞介素4（IL-4）和干扰素1（IFN-1）含量。结果感染组和非感染组中鼻腔细菌的分布以金黄色葡萄球菌最多（分别占58．6％和31．2％），其次是表皮葡萄球菌（分别占44．9％和46．7％）、肺炎杆菌（分别占7．9％和4．9％）、大肠杆菌（分别占3．5％和1．6％）；真菌主要为不解糖消化链球菌（分别占1．9％和1．6％）、迟缓真杆菌（分别占1．6％和0）和黏液真杆菌（分别占0．9％和0．8％）；病毒主要为合胞病毒、鼻病毒、腺病毒、流感病毒、副流感病毒和冠状病毒。伴有呼吸道感染的患者血清IL-4含量比非感染组显著增高（P〈0．05），而IFN-γ含量显著降低（P〈0．05）结论金黄色葡萄球菌、合胞病毒、鼻病毒、腺病毒、流感病毒与呼吸道的感染有密切的关系，可引起机体的免疫功能紊乱。Objective To explore microbic distribution feature of acute rhinitis patients＇nasal cavity and dependability research of respiratory infection. Methods 436 acute rhinitis patients were randomly divided to infection group（314） and non-infection group（122） depended on whether accompanying respiratory infection. Take blenna narium and carry out nasal cavity microbiological detection, meanwhile take blood and measure the content of serum IL- 4 and IFN-γ. Results The staphylococcus aureus taked the most proportion（58. 6% and 31.2% ） of nasal cavity bacterial distribution in infection group and non-infection group, the following bacterium were the staphylococcus epidermidis（44. 9% and 56.7% ）, bacillus meningitidis pumlentae（7.9% and 4. 9% ） and bacillus coli（3. 5% and 1.6% ）, the major eumycete were the peptostreptococcus asaccharolyticus （ 1.9% and 1.6% ）, eubacterium lentum （ 1.6% and 0） and eubacterium mucus（0. 9% and 0. 8% ） , the major virus were the syncytial virus, the rhinoviruadenovirus, influenza virus, parainfluenze virus and coronaviruses. The respiratory tract infection patients＇content of serum IL-4 were significant higher（ P 〈 0.05 ） than the non-infection group, but the content of IFN-γ were significantly reduced（P〈0.05）. Conclusion The staphylococcus aureus, syncytial virus, rhinoviruses, adenovirus and influenza virus have the close relation with the infection of the respiratory tract, which can cause the disorder of organism immune function.

关 键 词：鼻炎 微生物 分布 呼吸道感染 

分 类 号：R76[医药卫生—耳鼻咽喉科]