阻塞性睡眠呼吸暂停综合征患者血管内皮功能损害和相关炎症因子的研究  

Clinical study of vascular endothelial dysfunction and inflammation factors in patients with obstructive sleep apnea-hypopnea syndrome

作　　者：陆卫红[1] 王如兴[1] 羊镇宇[1] 崔小川[1] 曹云翔[1] 

机构地区：[1]无锡市人民医院心内科,江苏无锡214023

出　　处：《临床荟萃》2009年第5期384-386,共3页Clinical Focus

摘　　要：目的探讨阻塞性睡眠呼吸暂停综合征(OSAHS)严重程度和血管内皮功能损害及相关炎症因子的关系。方法选择在本院呼吸科和心内科住院的OSAHS患者120例,并按OSAHS的严重程度分为轻度、中度和重度3组,分别测定3组患者的血管性血友病因子(v WF)、C反应蛋白(CRP)、白细胞介素6(IL-6)及一氧化氮(NO)的水平,并应用高频超声检测血管内皮功能的主要指标(肱动脉基础内径,反应性充血后肱动脉内径变化率,口服硝酸甘油后肱动脉内径变化率,峰值流速变化率)。结果重度OSAHS组的v WF、CRP、IL-6水平分别为(356.3±59.7)%、(35.5±15.2)mg/L、(41.2±8.5)ng/L明显高于中度的(248.7±51.3)%、(26.2±12.3)mg/L、(34.7±7.6)ng/L和轻度组的(135.8±48.6)%、(15.3±8.9)mg/L、(25.9±6.8)ng/L,中度组明显高于轻度组(P<0.05),而重度组反应性充血后肱动脉内径变化率、峰值流速变化率、NO平均水平分别(7.19±2.08)%、(46.86±9.98)%、(7.8±5.6)μmol/L明显低于中度组的(13.45±3.01)%、(54.26±10.05)%、(10.6±6.1)μmol/L和轻度组的(21.10±2.25)%、(67.215±11.86)%、(15.6±7.3)μmol/L,中度组低于轻度组(P<0.05)。结论OSAHS严重程度和血管内皮功能损害程度及其炎症因子密切相关。Objective To analyze the relationship between the vascular endothelial dysfunction,the inflammation factors and the severity of OSAHS. Methods 120 patients who had been diagnosed of OSAHS were selected, by severity they were grouped into slight group, medium group and serious group, then serum von Willebrand factor （vWF）, C-reactive protein （CRP）, interleukin-6 （IL-6）, nitric oxide （NO） were detected, and main data （baseline of brachial artery,the flow-mediated dilatation and the nitroglycerin-induced dilatation, the peak flow speed dilatation） of endothelial function were measured by high resolution ultrasonography. Results The average level of serum vWF, CRP, IL-6 in serious group （356.3 ±59.7） %, （35.5 ± 15.2） mg/L, （41.2 ±8.5） ng/L were higher than those in slight group （135.8±48.6）% ,（15.3±8.9） mg/L,（25.9±6.8） ng/L and medium group （248.7±51.3） %, （26.2±12.3）mg/L, （34.7± 7.6） ng/L, the latters were higher than those of slight group; flow-mediated dilatation, the peak flow speed dilatation and serum nitric oxide in serious group （7.19 ± 2.08） %, （46.86 ± 9.98） %, （7.8 ± 5.6） μmol/L were lower than those in medium group （ 13.45 ± 3.01 ） %, （ 54.26± 10.05） %, （ 10.6 ± 6.1 ）μmol/L and slight group （21.10 ± 2.25） %, （ 67.22 ± 11.86） %, （15.6 ± 7.3）μmol/L, medium group ＇ s indexes were lower than those of slight group （ P 〈0.05）. Conclusion There is close relationship between the severity of OSAHS and the vascular endothelial dysfunction,the inflammation factors.

关 键 词：睡眠呼吸暂停 阻塞性 yon WILLEBRAND因子 C反应蛋白质 白细胞介素6 一氧化氮 血管 内皮 

分 类 号：R563[医药卫生—呼吸系统]