有机锗(Ge-132)对大鼠肝细胞色素P_(450)、EROD活性抑制作用的研究  

STUDY ON THE INHIBITION OF CYT P 450 CONTENT AND EROD ACTIVITY OF LIVER MICROSOMAL PREPARATION BY ORGANOAERMANIUM COMPOUNDS (G-132) IN RATS

作　　者：夏清林 莫白耀 杜琰琰 麦惠霞 

机构地区：[1]广州市卫生防疫站毒理科

出　　处：《癌变．畸变．突变》1998年第2期98-101,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：利用雄性ＳＤ大鼠每日经口给予有机锗（Ｇｅ－１３２）１００、２５０、５００ｍｇ／ｋｇ连续二十五ｄ，发现高剂量组的肝细胞色素Ｐ４５０受到明显抑制（Ｐ＜０．０５）。对Ｐ４４８的标志酶乙氧基异吩口恶唑脱乙氧基酶（ＥＲＯＤ）的抑制也近５０％；动物以Ｇｅ－１３２５００ｍｇ／ｋｇ／ｄ预先处理２０ｄ，再分别给予苯巴比妥钠盐（ＰＢ）、３－甲基胆蒽（３－ＭＣ），发现Ｇｅ－１３２对ＰＢ诱导Ｐ４５０的抑制不明显，而对３－ＭＣ诱导ＥＲＯＤ的抑制仍达３３％。Male SD rats were fed orally with Ge-132 100, 250 and 500mg/kg each day for 25 days, Cyt P 450 of liver cell of high dose group was inhibited significantly (P<0.05), EROD activity was also inhibited about 50 percent in the group compared with the control. The animals were pretreated with Ge-132 500mg/kg/d for 20 days, then give PB and 3-MC, found that the inhibition of P 450 induced by PB was not obvious, but there was 33 percent inhibition of EROD activity induced by 3-MC.

关 键 词：有机锗 锗132 肝细胞 P450 EROD活性 抑制作用 

分 类 号：R996[医药卫生—毒理学] R992[医药卫生—药学]