白行膨胀复合植入材料的实验研究  

Experimental study of PVPP/silicone composite automatic expanded material as implants

作　　者：尹卫民[1] 高建华[1] 杨青芳[2] 鲁峰[1] 叶佳佳[2] 

机构地区：[1]南方医科大学整形外科,广州510000 [2]西安西北工业大学理学院应化系高分子研究所

出　　处：《中华整形外科杂志》2009年第2期140-143,共4页Chinese Journal of Plastic Surgery

摘　　要：目的研究交联聚乙烯基吡咯烷酮水凝胶与硅橡胶共混，形成可自行膨胀的复合材料的可行性。方法将不同比例的复合材料植入24只新西兰白兔背部及鼻背皮下，与硅胶假体比较观察膨胀状况，和机体的反应及复合材料自行软组织扩张的效果。结果通过200d的连续观察，植入兔子皮下的复合材料按照设计膨胀量膨胀，与硅胶材料对比有明显的膨胀性，在一定的时间内最终达到平衡静止；通过组织切片检查，复合材料的周围组织的炎性反应和排斥反应与硅胶相同，上皮基底细胞的有丝分裂活跃。结论可自行膨胀的交联聚乙烯基吡咯烷酮硅橡胶复合材料具有优于硅胶的自行扩张膨胀性能，从而达到扩张软组织的目的。Objective To study the feasibility of Polyvinylpolypyrrolidone （PVPP）/silieone composite automatic expanded material as implants. Methods The PVPP hydrogel was mixed with silicone through the thioloeation at the high temperature. Implants with different ratio of PVPP to silicone were placed under the back and nose skin in 24 New Zealand rabbits. The surrounding tissue reaction, material and skin expansion were observed and compared with those with pure silicone implants. Results The study lasted for 200 days. Compared with pure silicone implants, the composite material could expand automatically and stop expanding at about 2 weeks after implantation. Histological study showed similar infectional and foreign body reaction around the composite material and the pure silicone. Conclusions Compared with pure silicone, the PVPP/silicone composite implant has the advantage of automatic expansion, so as to expand the soft tissue.

关 键 词：交联聚乙烯基吡咯烷酮 复合材料 自行膨胀 

分 类 号：R318.08[医药卫生—生物医学工程] R783.1[医药卫生—基础医学]