莫西沙星阴道泡腾栓的毒理学和药效学研究  

Toxicologic and pharmacodynamic study of Moxifloxacin Vaginal Effervescent Suppository

作　　者：梁少琼[1] 廖朝峰[1] 刘桂珍[1] 李国辉[1] 李蓉[2] 

机构地区：[1]深圳市宝安区人民医院药剂科,广东深圳518101 [2]深圳市南山区人民医院,广东深圳518052

出　　处：《中国医药导报》2009年第11期23-24,共2页China Medical Herald

摘　　要：目的:研究莫西沙星阴道泡腾栓(MVES)对豚鼠的毒理学和药效学。方法:对豚鼠分别采用单次及多次阴道给药,进行急性毒性和刺激性试验,并用3种质控致病菌感染豚鼠阴道,再用MVES治疗,并评价药效。结果:豚鼠给药前后全身状态无明显变化,刺激反应评分为0分;MVES低、中、高(23.5、47.0、94.0mg/kg)剂量阴道给药对金黄色葡萄球菌、铜绿假单胞菌和淋球菌的总转阴率分别为73.3%、83.3%和98.3%,与环丙沙星(75.0%)比较,与低剂量相当,无显著性差异(P>0.05),但量效关系明显。结论:MVES用于豚鼠疗效安全,未见明显毒性;对豚鼠质控致病菌阴道感染疗效明显。Objective： To study the toxicologic and pharmacodynamic effect of Moxifloxacin Vaginal Effervescent Suppository （MVES） on guinea pigs. Methods： MVES was guiven to guinea pigs through vagina as single and muhi-doses respectively, then the acute toxic and irritating tests were conducted. 3 kinds of control bacteria were used to infect the guinea pigs＇ vagina, then the guinea pigs were treated with MVES and the pharmacodynamics was evaluated. Results： There was no significant difference in the general state of the guinea pigs after treatment and the stimulation responses score was 0; MVES was administered to guinea pigs through vagina by 23.5, 47.0 and 94.0 mg/kg. The overall efficacy rates of MEVS for staphylococcus aurous, pseudomonas pyocyanea and gonococcus were 73.3%, 83.3% and 98.3% respectively. The over- all efficacy rate of Ciprofloxacin Vaginal Suppository （CVS） of 75.0% was equal to that of low dose of MEVS （P〉0.05）, and a clear dose-effect relationship was observed. Conclusion： MVES is safe and atoxic to guinea pigs, MVES has obvious efficacy in the treatment of control bacterial vaginal infection in guinea pigs.

关 键 词：莫西沙星 阴道泡腾栓 质控致病菌阴道感染 毒理学 药效学 

分 类 号：R96[医药卫生—药理学]