Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer  

作　　者：Ni Dai Ai-Ping Lu Cheng-Chao Shou Ji-You Li 

机构地区：[1]Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China [2]Department of Biochemistry & Molecular Biology, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China

出　　处：《World Journal of Gastroenterology》2009年第12期1499-1505,共7页世界胃肠病学杂志（英文版）

基　　金：Supported by Grant for Key Technology Research and Development Program 2002BA711A06;National Basic Research Priorities Program 973 Project 1998051203;the Ministry of Science and Technology of China,and grant H020920030390,from the Beijing Science and Technology Commission

摘　　要：AIM： To investigate the prognostic significance of phosphatase regenerating liver 3 （PRL-3） protein expression in gastric cancer.METHODS： PRL-3 expression in paraffin-embedded tumor specimens from 293 patients with gastric cancer was studied retrospectively by immunohistochemistry. Nonoclonal antibody specifically against PRL-3, 3B6, was obtained with hybridoma technique.RESULTS： Positive PRL-3 expression was detected in 43.3% （227 of 293） of gastric cancer cases. High expression of PRL-3 was positively correlated with tumor size, depth of invasion, vascular/lymphatic invasion, lymph node metastasis, high TNM stage and tumor recurrence. Patients with positive PRL-3 expression had a significantly lower 5-year survival rate than those with negative expression （28.3% vs 52.9%, P 〈 0.0001）. Patients who received curative surgery, and with positive PRL-3 expression had a significant shorter overall survival and disease-free disadvantage over patients with negative expression （hazard ratio of 16.7 and 16.6, respectively; P 〈 0.0001 for both）. Multivariate analysis revealed that PRL-3 expression was an independent prognostic indicator for overall and disease-free survival of gastric cancer patients, particularly for survival in TNM stage Ⅲ patients. CONCLUSION： PRL-3 expression is a new independent prognostic indicator to predict the potential of recurrence and survival in patients with gastric cancer at the time of tumor resection,AIM:To investigate the prognostic significance of phosphatase regenerating liver 3(PRL-3)protein expression in gastric cancer.METHODS:PRL-3 expression in paraffin-embedded tumor specimens from 293 patients with gastric cancer was studied retrospectively by immunohistochemistry.Monoclonal antibody specifically against PRL-3,3B6,was obtained with hybridoma technique.RESULTS:Positive PRL-3 expression was detected in 43.3%(127 of 293)of gastric cancer cases.High expression of PRL-3 was positively correlated with tumor size,depth of invasion,vascular/lymphatic invasion,lymph node metastasis,high TNM stage and tumor recurrence.Patients with positive PRL-3 expression had a significantly lower 5-year survival rate than those with negative expression(28.3%vs 51.9%,P<0.0001).Patients who received curative surgery,and with positive PRL-3 expression had a significant shorter overall survival and disease-free disadvantage over patients with negative expression(hazard ratio of 16.7 and 16.6,respectively;P<0.0001 for both).Multivariate analysis revealed that PRL-3 expression was an independent prognostic indicator for overall and disease-free survival of gastric cancer patients,particularly for survival in TNM stageⅢpatients.CONCLUSION:PRL-3 expression is a new independent prognostic indicator to predict the potential of recurrence and survival in patients with gastric cancer at the time of tumor resection.

关 键 词：Phosphatase regenerating liver 3 Gastriccancer PROGNOSIS RECURRENCE ANTIBODY 

分 类 号：R735.2[医药卫生—肿瘤] R737.9[医药卫生—临床医学]