泽泻对健康受试者血脂影响的临床对照研究  

The clinical control study on the effect of rhizoma alismatis on blood fat in health volunteers

作　　者：何雄伟[1] 

机构地区：[1]重庆市第九人民医院药剂科,重庆400700

出　　处：《重庆医科大学学报》2009年第3期376-378,共3页Journal of Chongqing Medical University

摘　　要：目的：探讨泽泻对不同类型的健康人群血脂的影响。方法：实验于2007年1月～2007年12月在重庆市第九人民医院完成。受试者26例，均为正常的健康人群。26名受试者服用泽泻颗粒，国食健字G20040383，上海生化科技开发中心提供，主要成分为泽泻，5g/袋，每日早晚各1次，1袋／次，2周为1个疗程，服用2个疗程。分别于服药前、服药后2周和4周后采血，采用日立7600自动生化分析仪依次检测血清蛋白胆固醇、载脂蛋白A、载脂蛋白B。分别探讨50岁以下受试者服用泽泻颗粒前后血脂变化和50岁以上受试者服用泽泻前后血脂变化。结果：50岁以下受试者服药2周后，三酰甘油水平有降低趋势，总胆固醇、低密度脂蛋白胆固醇水平与服药前相比，差异有显著性（P〈0．01），载脂蛋白A、载脂蛋白B、高密度脂蛋白胆固醇无变化；服药4周后，三酰甘油水平有降低趋势，总胆固醇、低密度脂蛋白胆固醇、载脂蛋白B水平与服药前相比。差异有显著性（P〈0．01），载脂蛋白A、高密度脂蛋白胆同醇无变化。50岁以上受试者服药2周后，总胆固醇水平有降低趋势，三酰甘油降低较明显，三酰甘油、低密度脂蛋白胆固醇水平与服药前相比，差异有显著性（P〈0．05）；载脂蛋白B比服药前降低明显，差异有显著性（P〈0．01），载脂蛋白A、高密度脂蛋白胆固醇无变化；4周后结果与2周后结果相同。结论：泽泻能有效降低健康人总胆固醇、载脂蛋白B、低密度脂蛋白胆固醇水平。Objective：To discuss the effect of Rhizoma Alismatis on blood fat in different health volunteers. Methods ：The experiment was finished in NO.9 People＇s Hospital of Chongqing, from January 2007 to December 2007.26 subjects were all healthy people. The 26 subjects took Rhizoma Alismatis granula（national food health product No. ： G20040383, provided by the biochemistry technology development center of Shanghai ）. The essential component was Rhizoma Alismatis, 5 g/pouch, taken once every morning and night, one pouch once time for two weeks as a course of treatment, two courses. Blood was drawn from the volunteers under the age of 50 years and above the age of 50 years before and after medication for two and four weeks, respectively. Serum protein cholesterol, apoprotein A, apoprotein B were detected by Hitachi 7 600 automatic biochemistry analyzer. Results ： In the volunteers under the age of 50 years, the level of triacylglycerol had a down tendency after 2 week medication. Compared with that before medication, the level of total cholesterol and low density lipoprotein cholesterol had significant difference （P〈0.01）,with no change in apoprotein A ,apoprotein B and high density lipoprotein cholesterol. After four week medication,the level of triacylglycerol had a down tendency. Compared with that before medication,the level of total cholesterol, low density lipoprotein cholesterol and apoprotein B had significant difference（P〈0.01 ）, with no change in apoproatein A and high density lipoprotein cholesterol. In the volunteers above the age of 50 years, after two weeks of medication, the level of total cholesterol had a down tendency, and triacylglycerol had a remarkable decrease. Compared with that before medication, the level of triacylglycerol and low density lipoprotein cholesterol had significant difference （P〈 0.05 ）. Apoprotein B had a noticeable decrease, with significant difference（P〈0.01 ） compared with that before medication. Apoproatein A and high density lipoprotein cho

关 键 词：泽泻 健康人群 总胆固醇 载脂蛋白B 低密度脂蛋白胆固醇 

分 类 号：R969.4[医药卫生—药理学]