参七汤对冠心病支架植入术后再狭窄的影响和机制探讨  

The Effect Mechanism of Shenqi Decoction on Restenosis after Implantation of Stents in Coronary Artery Disease

作　　者：赵华云[1] 王文会[1] 郞江明 陈伟强[1] 罗子幸[1] 余秀兰[1] 贺青军[1] 

机构地区：[1]广州中医药大学附属佛山市中医院

出　　处：《中西医结合心脑血管病杂志》2009年第4期382-384,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：广东省中医药管理局课题资助

摘　　要：目的观察参七汤对冠心病支架植入术后再狭窄的影响,并探讨其作用机制。方法冠心病支架植入术后患者68例,随机分为参七汤治疗组(治疗组,35例)和常规处理组(对照组,33例),随访6个月,观察再狭窄发生率、血小板活化标志物CD62P和炎症反应指标超敏C-反应蛋白(hs-CRP)。结果治疗组再狭窄率为14.29%低于对照组的36.36%(P<0.05)。PCI术后,CD62P和hs-CRP显著升高,加用参七汤治疗后,CD62P和hs-CRP水平较对照组明显降低(P<0.01)。6个月后,血瘀证计分治疗组显著低于对照组(P<0.01)。结论参七汤能有效减少冠心病PCI术后再狭窄的发生,减少斑块炎症反应,降低血小板活化水平,是其预防PCI术后再狭窄的机制之一。Objective To observe the effect of Shenqi Decoction on restenosis （RS） after implantation of stents in patients （pts） with coronary artery disease. Methods Sixty - eight pts with coronary artery disease after implantation of stents were randomly divided into two groups ： Shenqi Decoction group （n=35） and control group （n=33）. The RS rate,CD62P,high sensitive - and C - reactive protein （hs - CRP） wete studied, The effect of Shenqi Decoction was evaluated by scores of blood - stasis syndrome. Results The incidence of RS rate in Shenqi Decoction group was lower than that in the control group （P〈0. 05）. The level of CD62P and hs -CRP was significantly higher after percutaneous coronary intervention. After treatment with Shenqi Decoction, the level of CD62P and hs - CRP in Shenqi Decoction group was obviously degraded than that in control group （P〈0.01）. The blood - stasis syndrome scores in Shenqi Decoction group were significantly lower compared with that in control group after treatment for 6 months. Conclusion The Shenqi Decoction could effectively reduce the occurrence of restenosis. It might be due to reduce the inflammation reaction of plaque and to degrade the level of platelet activation.

关 键 词：参七汤 冠心痛 冠状动脉支榘植入术 再狭窄 

分 类 号：R259[医药卫生—中西医结合]