冠心病秽浊痰阻证与血浆t-PA、PAI-1及Fib的相关性研究  

The Correlativity Between Plasm t-PA,PAI-1 and Fibrinogen and Phlegm Syndrome Type of Coronary Heart Disease

作　　者：孙红艳[1] 安冬青[2] 宋刚[2] 

机构地区：[1]新疆医科大学 [2]新疆医科大学附属中医医院

出　　处：《中西医结合心脑血管病杂志》2009年第4期389-391,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的观察冠心病秽浊痰阻证和非秽浊痰阻证患者血浆组织型纤溶酶原激活物(t-PA)、组织型纤溶酶原激活物抑制物(PAI-1)及纤维蛋白原(Fib)的关系。方法选取新疆医科大学附属中医医院就诊的冠心病患者214例,其中秽浊痰阻证112例与非秽浊痰阻证102例,另设健康对照组103名,采用酶联免疫吸附双抗体夹心法原理检测t-PA、PAI-1,采用Clauss凝固法原理检测Fib。结果冠心病秽浊痰阻证组、非秽浊痰阻证组PAI-1明显高于健康对照组(P<0.0001);秽浊痰阻证组PAI-1高于非秽浊痰阻证组(P<0.05);但3组间t-PA和Fib均无统计学意义(P>0.05)。结论冠心病秽浊痰阻证和血浆PAI-1水平升高密切相关。Objective To observe the relation between plasma tissue plasminogen activator （t - PA） ,plasminogen activator inhibitor- 1 （PAI - 1） and fibrinogen （Fib） and TCM syndrome type of turbid sputum in coronary heart disease （CHD）. Methods One hundred and twelve CHD patients （pts） with syndrome type of turbid sputum,102 CHD pts without syndrome type of turbid sputum, and 103 healthy controls were studied. The level of plasma t - PA and PAI - 1 were detected by sandwich enzyme immunoassa：, technique,and fibrinogen was detected by Clauss solidify technique. Results The level of plasma PAl - 1 in CHD groups was higher obviously than that in healthy control group （P〈0. 000 1 ）. The level of plasma PAI- 1 in CHD group with syndrome type of turbid sputum was higher obviously than that in CHD group without syndrome type .of turbid sputum and in healthy control group （P〈0. 000 1）. There were no difference in level of plasma t - PA and fibrinogen among three groups （P〉0.05）. Conclusion There was closely relationship between TCM syndrome type of turbid sputum and plasma PAI- 1 level in coronary heart disease.

关 键 词：冠心病 秽浊痰阻证 纤维蛋白原 

分 类 号：R259[医药卫生—中西医结合]