大剂量纳洛酮气管内给药治疗新生儿重度窒息的临床观察  

High doge naloxone through intra-tracheal instillation for treating severe asphyxia in newborns

作　　者：冯振红[1] 杨晨[1] 李霞[1] 郭金莺[1] 

机构地区：[1]黑龙江省医院,黑龙江哈尔滨150036

出　　处：《中国医学装备》2009年第4期37-40,共4页China Medical Equipment

摘　　要：目的:观察大剂量纳洛酮气管内注入对新生儿重度窒息复苏效果的影响;方法:将生后约2min仍无自主呼吸的96例重度窒息新生儿列为观察对象。随机分为观察组30例,对照一组36例,另将未按本研究规则用药的30例患儿列为对照二组。观察组纳洛酮气管内注入剂量为0.1～0.13 mg/kg,对照一组除未用纳洛酮外,其他措施同观察组,对照二组开始用纳洛酮的时间大于生后4min,剂量小于0.09mg/kg;结果:观察组的所有患儿均被复苏,平均复苏时间为(6.87+2.87)min。对照一组中6例患儿即刻死亡,其余30例患儿平均复苏时间为(13.49+7.87)min。对照二组2例患儿即刻死亡,其他患儿平均复苏时间为(22.5+15)min。观察组平均复苏时间与对照一组及对照二组比较存在非常显著性差异(t=3.29,P<0.01;t=3.97,P<0.01);结论:大剂量纳洛酮气管内注入可缩短重度新生儿窒息的复苏时间。Objective： To observe effectiveness of high dose naloxone on resuscitation of the severe asphyxia in the neonates. Methods： Ninety-six babies were enrolled into the study. About 1-2 minutes after birth, they did not have spontaneous respiration. They were randomly assigned to the observed group （30cases） and the first control group （36cases）, other 30 eases in the second control group were not administered naloxone according to regulation. In the observed group, routine resuscitative saving, about 1-2 minutes after birth, if the newborns did not have spontaneous respiration, he or she was administered naloxone 0.1- 0.13mg/kg through intratracheal instillation. In the first control group, except for naloxone, other resuscitative methods were as same as the first control group. In the second control group, naloxone was administered more than 4- 5 minutes after birth, and the dose of naloxone was less than 0.09mg/kg Results：In observed group, all neonates were resuscitated successfully and the average resuscitative time was （6.87＋2.87）minutes. In the first control group, six cases failed to resuscitate and the average resuscitative time was （13.49＋7.87） minutes. In the second control group, two cases failed to resuscitate and the average resuscitative time was （22.5＋15） minutes. The average resuscitative time in naloxone group was different from the first control guoup and the second control group （t=3.92,P〈0.01,t=3.97,P〈0.01）. Conclusion：High dose of naloxone through intra-tracheal instillation could shorten the time of severe asphyxia in neonates.

关 键 词：重度窒息 新生儿 纳洛酮 

分 类 号：R197[医药卫生—卫生事业管理]