2型糖尿病中内皮细胞损伤及血小板功能状态的改变  

Change of the platelet functional state and vascular endothelial cell injury in diabetes mellitus

作　　者：崔红艳[1] 王芳[2] 

机构地区：[1]河南大学淮河临床学院,河南开封475001 [2]河南大学东京临床学院,河南开封475001

出　　处：《河南大学学报（医学版）》2009年第1期58-59,共2页Journal of Henan University:Medical Science

摘　　要：目的：观察2型糖尿病患者内皮细胞损伤及血小板功能状态的变化及临床意义。方法：利用双抗体夹心（ELISA）法测定血浆血管性血友病因子抗原（vWF：Ag）水平;采用玻珠柱法测定血小板黏附率（PAdT）。结果：vWF：Ag（160.8±35.6）%、PAdT（89.5±7.8）%水平显著高于无血管病变组,差异有显著意义（P〈0.05~0.01）。结论：2型糖尿病患者均存在血管内皮损伤,并由此引起血小板功能状态的改变;血浆vWF：Ag及PAdT水平在一定程度上可反映2型糖尿病患者血管病变的情况。Objective： To investigate vascular endothelial cell injury and the variation of the platelet functional appearance and its clinical value in type 2 diabetes patients. Methods： The plasma levels of von willebrand factor： antigen（vWF：Ag） was measured by ELISA.The adhesiveness of platelet was determined by salzman. Results： The plasma levels of these markers in group of type 2 diabetes with vascular complications were higher than those without vascular complications（P 〈0.05～0.01）. Conclusion： Type 2 diabetes patients exist vascular endothelial cell injury,the variation of the platelet functional appearance.The plasma levels of vWF：Ag and PAdT may reflect vascular pathological changes in type 2 diabetes patients to a certain extent.

关 键 词：糖尿病 内皮损伤 血管病变 

分 类 号：R587.1[医药卫生—内分泌]