单项乙型肝炎病毒核心抗体阳性的意义  

A STUDY ON ISOLATED ANTI-HBc POSITIVE OF HEPATITIS B

作　　者：孔令斌[1,2] 杨景玉[1,2] 王学良 徐慧文[1,2] 马玉莲 李清贤[1,2] 

机构地区：[1]济宁医学院附属医院 [2]西安医科大学病毒研究室

出　　处：《济宁医学院学报》1998年第1期30-32,共3页Journal of Jining Medical University

摘　　要：目的为阐明乙肝病毒单项抗－ＨＢｃ阳性的意义。方法对经放免严格筛选的５６名乙肝病毒单项抗－ＨＢｃ阳性者，１２１名乙肝ＨＢｓＡｇ、ＨＢｓＡｂ、ＨＢｃＡｂ三项指标全阴性者均按０、１、６月方案接种同样的乙肝疫苗。在表面抗体出现高峰期（即接种乙肝疫苗后第９个月时），比较二者抗－ＨＢｓ的应答率。结果单项抗－ＨＢｃ阳性组明显低于后者，提示乙肝病毒单项抗－ＨＢｃ阳性者可能与ＨＢＶ感染有关。为了进一步证实这一结论，我们又用ＰＣＲ法检测了５６例单项抗－ＨＢｃ阳性者外周血清的ＨＢＶ－ＤＮＡ，结果有１６例ＨＢＶ－ＤＮＡ阳性。结论表明多数情况下单项抗－ＨＢｃ阳性者为ＨＢＶ感染的指标，少数情况下为ＨＢＶ感染后遗留的标志。Objective To study the relationship between isolated anti-HBe and HBV inflection.Methods We screend 56 isolated anti-HBc postives and 121 HBsAg,anti-HBs,anti-HBc all negatives from 600 pupils with SP-RIA,inoculated them at 0,1,6 month intervals,blood samples and collected at T9 for examining anti-HBs.Results It indicated that the response rate of isolated anti-HBc positives was lower than that of HBsAg,anti-HBs,anti-HBc all negatives.PCR technique was used in 56 pupils with isolated anti-HBc,and proved that in of 16 them HBV-DNA was positive.Conclusion That indicated that the ralationship between isolated anti-HBc and HBV inflection cant be denied.

关 键 词：乙型肝炎病毒 单项抗-HBc 阳性 

分 类 号：R373.21[医药卫生—病原生物学]