乙肝Ⅰ号方对实验性急性肝损伤小鼠抗自由基损伤作用  

Antioxidation of Prescription No.1 for Anti-hepatitis B in Experimental Mice with Acute Hepatic Injury

作　　者：钱涯邻[1] 孙沛毅[2] 孙云[2] 张洪泉[2] 

机构地区：[1]扬州江苏省苏北人民医院 [2]扬州大学医药研究中心

出　　处：《南京铁道医学院学报》1998年第1期7-9,共3页Journal of Nanjing Railway Medical College

基　　金：江苏省省科委课题

摘　　要：目的：研究乙肝Ⅰ号方对实验性急性肝损伤小鼠抗氧自由基损伤的作用及其机制。方法：采用ｄ－氨基半乳糖急性肝损伤模型，观察小鼠肝匀浆丙二醛（ＭＤＡ）含量、超氧化物歧化酶（ＳＯＤ）及血清酶学改变。结果：乙肝Ⅰ号方防治组与对照组相比，小鼠肝损伤明显减轻，肝匀浆ＭＤＡ含量下降，血清ＡＬＴ降低，降低程度与用药量呈明显的量效关系，且抗氧自由基作用优于乙肝灵冲剂。Objective:Prescription No 1 for anti-hepatitis B(P1AHB),was studied for its antioxidation in experimental hepatic injury.Method:The acute hepatic injury was induced by peritoneoinjection with d-galactosamine in mice.The liver tissue and blood samples were taken and measured for the level of malonyldialdehyde(MDA),and for the change of superoxide dismutase (SOD) in liver and serum glutamic pyruvic transaminase (SGPT) in blood.Result:Compared with control animals,P1AHB can dose-dependently inhibit the increased MDA in liver and SGPT in blood.Therefore the hepatic injury was alleviated.Conclusion:It is suggested that the therapeutical action of P1AHB on hepatitis B be associated with its antioxidation

关 键 词：谷丙转氨酶 丙二醛 乙型肝炎 中医药疗法 

分 类 号：R259.126.2[医药卫生—中西医结合]